Human CD81 Recombinant Protein (RPPB3094)

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SKU:
RPPB3094
Product type:
Recombinant Protein
Size:
10ug
Species:
Human
Target:
CD81
Synonyms:
CD81 Molecule
Synonyms:
CD81 Antigen (Target Of Antiproliferative Antibody 1)
Synonyms:
26 KDa Cell Surface Protein TAPA-1
Synonyms:
Tetraspanin-28
Source:
Sf9 Insect cells
Uniprot:
P60033
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Description

Product Name:Human CD81 Recombinant Protein
Product Code:RPPB3094
Size:10µg
Species:Human
Target:CD81
Synonyms:CD81 Molecule, CD81 Antigen (Target Of Antiproliferative Antibody 1), 26 KDa Cell Surface Protein TAPA-1, Tetraspanin-28, CD81 Antigen, Tspan-28, TSPAN28, TAPA1, Target Of The Antiproliferative Antibody 1, CVID6, S5.7, 26 kDa cell surface protein TAPA-1, Target of the antiproliferative antibody 1, Tetraspanin-28, Tspan-28.
Source:Sf9 Insect cells
Physical Appearance:Sterile filtered colorless solution.
Formulation:CD81 protein solution (0.5mg/ml) contains Phosphate Buffered Saline (pH 7.4) and 10% glycerol.
Stability:Store at 4°C if entire vial will be used within 2-4 weeks.Store, frozen at -20°C for longer periods of time. For long term storage it is recommended to add a carrier protein (0.1% HSA or BSA).Avoid multiple freeze-thaw cycles.
Purity:Greater than 95.0% as determined by SDS-PAGE.
Amino Acid Sequence:ADPFVNKDQI AKDVKQFYDQ ALQQAVVDDD ANNAKAVVKT FHETLDCCGS STLTALTTSV LKNNLCPSGS NIISNLFKED CHQKIDDLFS GKLEPKSCDK THTCPPCPAP ELLGGPSVFL FPPKPKDTLM ISRTPEVTCV VVDVSHEDPE VKFNWYVDGV EVHNAKTKPR EEQYNSTYRV VSVLTVLHQD WLNGKEYKCK VSNKALPAPI EKTISKAKGQ PREPQVYTLP PSRDELTKNQ VSLTCLVKGF YPSDIAVEWE SNGQPENNYK TTPPVLDSDG SFFLYSKLTV DKSRWQQGNV FSCSVMHEAL HNHYTQKSLS LSPGKHHHHH H

CD81 antigen isoform 1, also known as CD81, is part of the tetraspanin family. CD81 interacts directly with immunoglobulin superfamily member 8 (IGSF8, CD316) and CD36. In B cells, CD81 is part of a complex with CD21, CD19 and Leu13. Furthermore, this complex decreases the threshold for B cell activation through B cell receptors by linking Ag specific recognition and CD21 mediator recognition. While on T cells CD81 connects with CD4 and CD8 and provides a costimulatory signal with CD3.

CD81 produced in Sf9 Baculovirus cells is a single, glycosylated polypeptide chain containing 331 amino acids (113-201a.a.) and having a molecular mass of 37.0kDa. (Molecular size on SDS-PAGE will appear at approximately 40-57kDa).CD81 is expressed with a 242 amino acid hIgG-His-tag at C-Terminus and purified by proprietary chromatographic techniques.

UniProt Protein Function:May play an important role in the regulation of lymphoma cell growth. Interacts with a 16-kDa Leu-13 protein to form a complex possibly involved in signal transduction. May act as the viral receptor for HCV.(Microbial infection) Acts as a receptor for hepatitis C virus (HCV) in hepatocytes. Associates with CLDN1 and the CLDN1-CD81 receptor complex is essential for HCV entry into host cell.
NCBI Summary:The protein encoded by this gene is a member of the transmembrane 4 superfamily, also known as the tetraspanin family. Most of these members are cell-surface proteins that are characterized by the presence of four hydrophobic domains. The proteins mediate signal transduction events that play a role in the regulation of cell development, activation, growth and motility. This encoded protein is a cell surface glycoprotein that is known to complex with integrins. This protein appears to promote muscle cell fusion and support myotube maintenance. Also it may be involved in signal transduction. This gene is localized in the tumor-suppressor gene region and thus it is a candidate gene for malignancies. Two transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Jul 2014]
UniProt Code:P60033
NCBI GenInfo Identifier:38503376
NCBI Gene ID:975
NCBI Accession:P60033.1
UniProt Related Accession:P60033
Molecular Weight:
NCBI Full Name:CD81 antigen
NCBI Synonym Full Names:CD81 molecule
NCBI Official Symbol:CD81  
NCBI Official Synonym Symbols:S5.7; CVID6; TAPA1; TSPAN28  
NCBI Protein Information:CD81 antigen
UniProt Protein Name:CD81 antigen
UniProt Synonym Protein Names:26 kDa cell surface protein TAPA-1; Target of the antiproliferative antibody 1; Tetraspanin-28; Tspan-28; CD_antigen: CD81
Protein Family:CD81 antigen
UniProt Gene Name:CD81  
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