Human CD80 Recombinant Protein (RPPB5879)

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SKU:
RPPB5879
Product type:
Recombinant Protein
Size:
5ug
Species:
Human
Target:
CD80
Synonyms:
CD80 Molecule
Synonyms:
CD80 Antigen (CD28 Antigen Ligand 1
Synonyms:
B7-1 Antigen)
Synonyms:
B-Lymphocyte Activation Antigen B7
Source:
Sf9 Insect cells
Uniprot:
P33681
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Description

Product Name:Human CD80 Recombinant Protein
Product Code:RPPB5879
Size:5µg
Species:Human
Target:CD80
Synonyms:CD80 Molecule, CD80 Antigen (CD28 Antigen Ligand 1, B7-1 Antigen), B-Lymphocyte Activation Antigen B7, CTLA-4 Counter-Receptor B7.1, Activation B7-1 Antigen, CD28LG1, CD28LG, LAB7, BB1, B7, Costimulatory Molecule Variant IgV-CD80, T-Lymphocyte Activation Antigen CD80, Costimulatory Factor CD80, CD80 Antigen, B7-1, B7.1.
Source:Sf9 Insect cells
Formulation:CD80 protein solution (0.5mg/ml) contains Phosphate Buffered Saline (pH 7.4) and 10% glycerol.
Stability:Store at 4°C if entire vial will be used within 2-4 weeks. Store, frozen at -20°C for longer periods of time. For long term storage it is recommended to add a carrier protein (0.1% HSA or BSA).Avoid multiple freeze-thaw cycles.
Purity:Greater than 95.0% as determined by SDS-PAGE.
Amino Acid Sequence:VIHVTKEVKE VATLSCGHNV SVEELAQTRI YWQKEKKMVL TMMSGDMNIW PEYKNRTIFD ITNNLSIVIL ALRPSDEGTY ECVVLKYEKD AFKREHLAEV TLSVKADFPT PSISDFEIPT SNIRRIICST SGGFPEPHLS WLENGEELNA INTTVSQDPE TELYAVSSKL DFNMTTNHSF MCLIKYGHLR VNQTFNWNTT KQEHFPDNLE HHHHHH

CD80 which is a member of cell surface immunoglobulin superfamily takes part in the costimulatory signal essential for T-lymphocyte activation. CD80 binds to either human or mouse CD28 and CTLA-4 – binding to CD28 induces T-cell proliferation and cytokine production while binding to CTLA-4 inhibits T-cell activation. CD80 is expressed on activated B cells, activated T cells, and macrophages.

CD80 Human Recombinant produced in Sf9 Insect cells is a single, glycosylated polypeptide chain containing 216 amino acids (35-242a.a.) and having a molecular mass of 24.9kDa (Molecular size on SDS-PAGE will appear at approximately 28-40kDa).CD80 is expressed with an 8 amino acid His tag at C-Terminus and purified by proprietary chromatographic techniques.

UniProt Protein Function:Involved in the costimulatory signal essential for T-lymphocyte activation. T-cell proliferation and cytokine production is induced by the binding of CD28, binding to CTLA-4 has opposite effects and inhibits T-cell activation.
NCBI Summary:The protein encoded by this gene is a membrane receptor that is activated by the binding of CD28 or CTLA-4. The activated protein induces T-cell proliferation and cytokine production. This protein can act as a receptor for adenovirus subgroup B and may play a role in lupus neuropathy. [provided by RefSeq, Aug 2011]
UniProt Code:P33681
NCBI GenInfo Identifier:461606
NCBI Gene ID:941
NCBI Accession:P33681.1
UniProt Secondary Accession:P33681,Q5DTA9, Q5DTB0,
UniProt Related Accession:P33681
Molecular Weight:18,761 Da
NCBI Full Name:T-lymphocyte activation antigen CD80
NCBI Synonym Full Names:CD80 molecule
NCBI Official Symbol:CD80  
NCBI Official Synonym Symbols:B7; BB1; B7-1; B7.1; LAB7; CD28LG; CD28LG1  
NCBI Protein Information:T-lymphocyte activation antigen CD80
UniProt Protein Name:T-lymphocyte activation antigen CD80
UniProt Synonym Protein Names:Activation B7-1 antigen; BB1; CTLA-4 counter-receptor B7.1; B7; CD_antigen: CD80
Protein Family:T-lymphocyte activation antigen
UniProt Gene Name:CD80  
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