Human CD80 Recombinant Protein (RPPB5879)
- SKU:
- RPPB5879
- Product type:
- Recombinant Protein
- Size:
- 5ug
- Species:
- Human
- Target:
- CD80
- Synonyms:
- CD80 Molecule
- CD80 Antigen (CD28 Antigen Ligand 1
- B7-1 Antigen)
- B-Lymphocyte Activation Antigen B7
- Source:
- Sf9 Insect cells
- Uniprot:
- P33681
Description
| Product Name: | Human CD80 Recombinant Protein |
| Product Code: | RPPB5879 |
| Size: | 5µg |
| Species: | Human |
| Target: | CD80 |
| Synonyms: | CD80 Molecule, CD80 Antigen (CD28 Antigen Ligand 1, B7-1 Antigen), B-Lymphocyte Activation Antigen B7, CTLA-4 Counter-Receptor B7.1, Activation B7-1 Antigen, CD28LG1, CD28LG, LAB7, BB1, B7, Costimulatory Molecule Variant IgV-CD80, T-Lymphocyte Activation Antigen CD80, Costimulatory Factor CD80, CD80 Antigen, B7-1, B7.1. |
| Source: | Sf9 Insect cells |
| Formulation: | CD80 protein solution (0.5mg/ml) contains Phosphate Buffered Saline (pH 7.4) and 10% glycerol. |
| Stability: | Store at 4°C if entire vial will be used within 2-4 weeks. Store, frozen at -20°C for longer periods of time. For long term storage it is recommended to add a carrier protein (0.1% HSA or BSA).Avoid multiple freeze-thaw cycles. |
| Purity: | Greater than 95.0% as determined by SDS-PAGE. |
| Amino Acid Sequence: | VIHVTKEVKE VATLSCGHNV SVEELAQTRI YWQKEKKMVL TMMSGDMNIW PEYKNRTIFD ITNNLSIVIL ALRPSDEGTY ECVVLKYEKD AFKREHLAEV TLSVKADFPT PSISDFEIPT SNIRRIICST SGGFPEPHLS WLENGEELNA INTTVSQDPE TELYAVSSKL DFNMTTNHSF MCLIKYGHLR VNQTFNWNTT KQEHFPDNLE HHHHHH |
CD80 which is a member of cell surface immunoglobulin superfamily takes part in the costimulatory signal essential for T-lymphocyte activation. CD80 binds to either human or mouse CD28 and CTLA-4 – binding to CD28 induces T-cell proliferation and cytokine production while binding to CTLA-4 inhibits T-cell activation. CD80 is expressed on activated B cells, activated T cells, and macrophages.
CD80 Human Recombinant produced in Sf9 Insect cells is a single, glycosylated polypeptide chain containing 216 amino acids (35-242a.a.) and having a molecular mass of 24.9kDa (Molecular size on SDS-PAGE will appear at approximately 28-40kDa).CD80 is expressed with an 8 amino acid His tag at C-Terminus and purified by proprietary chromatographic techniques.
| UniProt Protein Function: | Involved in the costimulatory signal essential for T-lymphocyte activation. T-cell proliferation and cytokine production is induced by the binding of CD28, binding to CTLA-4 has opposite effects and inhibits T-cell activation. |
| NCBI Summary: | The protein encoded by this gene is a membrane receptor that is activated by the binding of CD28 or CTLA-4. The activated protein induces T-cell proliferation and cytokine production. This protein can act as a receptor for adenovirus subgroup B and may play a role in lupus neuropathy. [provided by RefSeq, Aug 2011] |
| UniProt Code: | P33681 |
| NCBI GenInfo Identifier: | 461606 |
| NCBI Gene ID: | 941 |
| NCBI Accession: | P33681.1 |
| UniProt Secondary Accession: | P33681,Q5DTA9, Q5DTB0, |
| UniProt Related Accession: | P33681 |
| Molecular Weight: | 18,761 Da |
| NCBI Full Name: | T-lymphocyte activation antigen CD80 |
| NCBI Synonym Full Names: | CD80 molecule |
| NCBI Official Symbol: | CD80 |
| NCBI Official Synonym Symbols: | B7; BB1; B7-1; B7.1; LAB7; CD28LG; CD28LG1 |
| NCBI Protein Information: | T-lymphocyte activation antigen CD80 |
| UniProt Protein Name: | T-lymphocyte activation antigen CD80 |
| UniProt Synonym Protein Names: | Activation B7-1 antigen; BB1; CTLA-4 counter-receptor B7.1; B7; CD_antigen: CD80 |
| Protein Family: | T-lymphocyte activation antigen |
| UniProt Gene Name: | CD80 |
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