Human CD79B Recombinant Protein (RPPB3092)
- SKU:
- RPPB3092
- Product type:
- Recombinant Protein
- Size:
- 20ug
- Species:
- Human
- Target:
- CD79B
- Synonyms:
- AGM6
- B29
- IGB
- B-cell antigen receptor complex-associated protein beta chain
- Source:
- Escherichia Coli
- Uniprot:
- P40259
Description
| Product Name: | Human CD79B Recombinant Protein |
| Product Code: | RPPB3092 |
| Size: | 20µg |
| Species: | Human |
| Target: | CD79B |
| Synonyms: | AGM6, B29, IGB, B-cell antigen receptor complex-associated protein beta chain, B-cell-specific glycoprotein B29, B-cell-specific glycoprotein B29, Immunoglobulin-associated B29 protein, CD79b, CD antigen, CD79b. |
| Source: | Escherichia Coli |
| Physical Appearance: | Sterile Filtered colorless solution. |
| Formulation: | CD79B protein solution (1mg/ml) contains 20mM Tris-HCl buffer (pH 8.0), 2M UREA and 10% glycerol. |
| Stability: | Store at 4°C if entire vial will be used within 2-4 weeks. Store, frozen at -20°C for longer periods of time. For long term storage it is recommended to add a carrier protein (0.1% HSA or BSA).Avoid multiple freeze-thaw cycles. |
| Purity: | Greater than 90% as determined by SDS-PAGE. |
| Amino Acid Sequence: | MGSSHHHHHH SSGLVPRGSH MGSMARSEDR YRNPKGSACS RIWQSPRFIA RKRGFTVKMH CYMNSASGNV SWLWKQEMDE NPQQLKLEKG RMEESQNESL ATLTIQGIRF EDNGIYFCQQ KCNNTSEVYQ GCGTELRVMG FSTLAQLKQR NTLKD |
CD79B is a 36 kDa trans membrane glycoprotein belonging to the immunoglobulin superfamily. Heterodimers of CD79A and CD79B connect with a membrane attached immunoglobulin on the B cell surface to create the B cell antigen receptor complex (BCR). CD79A and CD79B are essential for BCR-mediated signaling and subsequently for the development and activation of B lineage cells.
CD79B Human Recombinant produced in E.Coli is a single, non-glycosylated polypeptide chain containing 155 amino acids (29-159a.a) and having a molecular mass of 17.7kDa. CD79B is fused to a 24 amino acid His-tag at N-terminus & purified by proprietary chromatographic techniques.
| UniProt Protein Function: | Ig-beta: Required in cooperation with CD79A for initiation of the signal transduction cascade activated by the B-cell antigen receptor complex (BCR) which leads to internalization of the complex, trafficking to late endosomes and antigen presentation. Enhances phosphorylation of CD79A, possibly by recruiting kinases which phosphorylate CD79A or by recruiting proteins which bind to CD79A and protect it from dephosphorylation. Defects in CD79B are the cause of agammaglobulinemia type 6 (AGM6). It is a primary immunodeficiency characterized by profoundly low or absent serum antibodies and low or absent circulating B-cells due to an early block of B-cell development. Affected individuals develop severe infections in the first years of life. 2 isoforms of the human protein are produced by alternative splicing. |
| UniProt Protein Details: | Protein type:Receptor, misc.; Membrane protein, integral Chromosomal Location of Human Ortholog: 17q23 Cellular Component: nucleoplasm; Golgi apparatus; integral to plasma membrane; cytoplasm; plasma membrane; B cell receptor complex; external side of plasma membrane Molecular Function:transmembrane receptor activity Biological Process: B cell receptor signaling pathway; immune response; signal transduction Disease: Agammaglobulinemia 6, Autosomal Recessive |
| NCBI Summary: | The B lymphocyte antigen receptor is a multimeric complex that includes the antigen-specific component, surface immunoglobulin (Ig). Surface Ig non-covalently associates with two other proteins, Ig-alpha and Ig-beta, which are necessary for expression and function of the B-cell antigen receptor. This gene encodes the Ig-beta protein of the B-cell antigen component. Alternatively spliced transcript variants encoding different isoforms have been described. [provided by RefSeq, Jul 2008] |
| UniProt Code: | P40259 |
| NCBI GenInfo Identifier: | 728994 |
| NCBI Gene ID: | 974 |
| NCBI Accession: | P40259.1 |
| UniProt Secondary Accession: | P40259,Q53FS2, Q9BU06, |
| UniProt Related Accession: | P40259 |
| Molecular Weight: | 229 |
| NCBI Full Name: | B-cell antigen receptor complex-associated protein beta chain |
| NCBI Synonym Full Names: | CD79b molecule, immunoglobulin-associated beta |
| NCBI Official Symbol: | CD79B |
| NCBI Official Synonym Symbols: | B29; IGB; AGM6 |
| NCBI Protein Information: | B-cell antigen receptor complex-associated protein beta chain; Ig-beta; B-cell-specific glycoprotein B29; immunoglobulin-associated B29 protein; CD79b antigen (immunoglobulin-associated beta) |
| UniProt Protein Name: | B-cell antigen receptor complex-associated protein beta chain |
| UniProt Synonym Protein Names: | B-cell-specific glycoprotein B29; Ig-beta; Immunoglobulin-associated B29 protein; CD_antigen: CD79b |
| UniProt Gene Name: | CD79B |
| UniProt Entry Name: | CD79B_HUMAN |
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