Human CD79A Recombinant Protein (RPPB3091)
- SKU:
- RPPB3091
- Product type:
- Recombinant Protein
- Size:
- 10ug
- Species:
- Human
- Target:
- CD79A
- Synonyms:
- Membrane-Bound Immunoglobulin-Associated Protein
- CD79A Antigen (Immunoglobulin-Associated Alpha)
- Source:
- Sf9 Insect cells
- Uniprot:
- P11912
Description
| Product Name: | Human CD79A Recombinant Protein |
| Product Code: | RPPB3091 |
| Size: | 10µg |
| Species: | Human |
| Target: | CD79A |
| Synonyms: | CD79a Molecule, Membrane-Bound Immunoglobulin-Associated Protein, CD79A Antigen (Immunoglobulin-Associated Alpha), CD79a Molecule, Immunoglobulin-Associated Alpha, Surface IgM-Associated Protein, MB-1 Membrane Glycoprotein, Ig-Alpha, IGA, B-Cell Antigen Receptor Complex-Associated Protein Alpha Chain, CD79a Antigen, MB-1, MB1. |
| Source: | Sf9 Insect cells |
| Formulation: | CD79A protein solution (1mg/ml) contains Phosphate Buffered Saline (pH 7.4) and 10% glycerol. |
| Stability: | Store at 4°C if entire vial will be used within 2-4 weeks. Store, frozen at -20°C for longer periods of time. For long term storage it is recommended to add a carrier protein (0.1% HSA or BSA).Avoid multiple freeze-thaw cycles. |
| Purity: | Greater than 95.0% as determined by SDS-PAGE. |
| Amino Acid Sequence: | LWMHKVPASL MVSLGEDAHF QCPHNSSNNA NVTWWRVLHG NYTWPPEFLG PGEDPNGTLI IQNVNKSHGG IYVCRVQEGN ESYQQSCGTY LRVRQPPPRP FLDMGEGTKN RLEHHHHHH |
CD79A is a signal-transducing part of the B-cell receptor which plays various roles in B cell development and function. CD79A is also needed for BCR surface expression and for efficient differentiation of pro-B and pre-B-cells. CD79A plays an important role in the tumor promoting effects of myeloid cells, and is a novel target for cancer therapy.
CD79A Human Recombinant produced in Sf9 Insect cells is a single, glycosylated polypeptide chain containing 119 amino acids (33-143a.a.) and having a molecular mass of 13.6kDa (Molecular size on SDS-PAGE will appear at approximately 18-28kDa).CD79A is expressed with a 8 amino acid His tag at C-Terminus and purified by proprietary chromatographic techniques.
| UniProt Protein Function: | Ig-alpha: an integral membrane protein that associates with surface immunoglobulin B lymphocyte antigen receptor multimeric complex. Surface Ig non-covalently associates with 2 other proteins, Ig-alpha and Ig-beta, which are necessary for expression and function of the B-cell antigen receptor. Two alternatively spliced isoforms have been described. |
| UniProt Protein Details: | Protein type:Membrane protein, integral; Immunoglobulin superfamily Chromosomal Location of Human Ortholog: 19q13.2 Cellular Component: B cell receptor complex; cytoplasm; external side of plasma membrane; integral to plasma membrane; lipid raft; multivesicular body; plasma membrane Molecular Function:protein binding Biological Process: B cell activation; B cell differentiation; B cell proliferation; B cell receptor signaling pathway Disease: Agammaglobulinemia 3, Autosomal Recessive |
| NCBI Summary: | The B lymphocyte antigen receptor is a multimeric complex that includes the antigen-specific component, surface immunoglobulin (Ig). Surface Ig non-covalently associates with two other proteins, Ig-alpha and Ig-beta, which are necessary for expression and function of the B-cell antigen receptor. This gene encodes the Ig-alpha protein of the B-cell antigen component. Alternatively spliced transcript variants encoding different isoforms have been described. [provided by RefSeq, Jul 2008] |
| UniProt Code: | P11912 |
| NCBI GenInfo Identifier: | 547896 |
| NCBI Gene ID: | 973 |
| NCBI Accession: | P11912.2 |
| UniProt Secondary Accession: | P11912,Q53FB8, A0N775, |
| UniProt Related Accession: | P11912 |
| Molecular Weight: | 20,786 Da |
| NCBI Full Name: | B-cell antigen receptor complex-associated protein alpha chain |
| NCBI Synonym Full Names: | CD79a molecule |
| NCBI Official Symbol: | CD79A |
| NCBI Official Synonym Symbols: | IGA; MB-1 |
| NCBI Protein Information: | B-cell antigen receptor complex-associated protein alpha chain |
| UniProt Protein Name: | B-cell antigen receptor complex-associated protein alpha chain |
| UniProt Synonym Protein Names: | Ig-alpha; MB-1 membrane glycoprotein; Membrane-bound immunoglobulin-associated protein; Surface IgM-associated protein; CD_antigen: CD79a |
| Protein Family: | B-cell antigen receptor complex-associated protein |
| UniProt Gene Name: | CD79A |
| UniProt Entry Name: | CD79A_HUMAN |
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