PE/Cyanine7 Anti-Human CD74 Antibody [LN2] (AGEL1055)

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SKU:
AGEL1055
Product Type:
Antibody
Antibody Type:
Monoclonal Antibody
Reactivity:
Human
Applications:
FC
Frequently bought together:

Description

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PE/Cyanine7 Anti-Human CD74 Antibody [LN2]

The Human CD74 Monoclonal Antibody (PE/Cyanine7 Conjugated) LN2 (AGEL1055) is a cutting-edge tool designed for scientists and researchers investigating CD74, a key protein involved in the immune response and antigen presentation pathways. This monoclonal antibody, specifically engineered for human samples, offers exceptional sensitivity and specificity in flow cytometry and fluorescence microscopy applications.CD74, also known as the MHC class II-associated invariant chain, plays a pivotal role in the adaptive immune system by facilitating antigen presentation and promoting immune responses. Its involvement in various immune-related processes makes it a crucial target for studies in immunology, oncology, and infectious diseases research.

The CD74 Monoclonal Antibody enables precise detection and visualization of CD74 expression in different cell types, aiding in the understanding of its function and potential therapeutic implications.Researchers can utilize this high-quality antibody to explore the role of CD74 in immune cell activation, antigen processing, and immune surveillance mechanisms. By unraveling the intricate mechanisms of CD74-mediated immune responses, scientists can gain insights into immune system regulation and develop novel strategies for combating diseases such as cancer, autoimmune disorders, and infectious pathogens. Unlock the potential of CD74 research with the precise and reliable CD74 Monoclonal Antibody (PE/Cyanine7 Conjugated) LN2 (AGEL1055).

Product Title:PE/Cyanine7 Anti-Human CD74 Antibody [LN2]
SKU:AGEL1055
Size:20 Tests, 100 Tests, 200 Tests
Clone No:LN2
Synonyms:HLA class II histocompatibility antigen gamma chain;CD74;Ia antigen-associated invariant chain;Ii;p33;DHLAG;
Host Species:Mouse
Reactivity:Human
Application:FCM
Isotype:Mouse IgG1, κ
Isotype Control:PE/Cyanine7 Mouse IgG1, κ Isotype Control[MOPC-21]
Form:Liquid
Conjugation:PE/Cyanine 7
Recommended Use:Each lot of this antibody is quality control tested by flow cytometric analysis. The amount of the reagent is suggested to be used 5 µL of antibody per test (million cells in 100 µL staining volume or per 100 µL of whole blood). Please check your vial before the experiment. Since applications vary, the appropriate dilutions must be determined for individual use.
Spectrum:Spectrum Image
Swissprot:P04233
Gene ID:972
Storage Buffer:Phosphate buffered solution, pH 7.2, containing 0.09% stabilizer and 1% protein protectant.
Stability & Storage:Keep as concentrated solution. Store at 2~8°C and protected from prolonged exposure to light. Do not freeze. Centrifuge before opening to ensure complete recovery of vial contents. This product is guaranteed up to one year from purchase.
Background:CD74 is a type II transmembrane glycoprotein also known as MHC class II associated invariant chain, invariant chain, Ii, MHC class II chaperone, and MIF receptor. CD74 exists in four isoforms with molecular masses of 33, 35, 41, and 43 kD, depending on genetic splicing. CD74 is primarily expressed on antigen presenting cells, including B cells, monocytes/macrophages, dendritic cells, and Langerhans cells. It is also expressed by activated T cells and activated endothelial and epithelial cells as well as carcinomas of lung, renal, gastric and thymic origin. The primary function of CD74 is intracellular sorting of MHC class II molecules and regulation of exogenous peptide loading onto MHC class II. It is also involved in the modulation of B cell differentiation and positive selection of CD4+ T cells. It has been reported that CD74 binds MIF (macrophage migration inhibitory factor) and signals through CD44 to regulate innate and adaptive immunity. It is also reported that H. pylori infection occurs through urease B binding of CD74 on gastric epithelial cells, inducing gastric epithelial cell apoptosis, NF-κB activation, and IL-8 production.

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