GenieFluor 488 Anti-Human CD74 Antibody [LN2] (AGEL1058)

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SKU:
AGEL1058
Product Type:
Antibody
Antibody Type:
Monoclonal Antibody
Reactivity:
Human
Applications:
FC
Frequently bought together:

Description

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GenieFluor 488 Anti-Human CD74 Antibody [LN2]

The Human CD74 Monoclonal Antibody (AF488 Conjugated) LN2 (AGEL1058) is a specialized tool for researchers investigating CD74, a cell surface glycoprotein involved in antigen presentation and immune response modulation. This monoclonal antibody, conjugated with AF488 for fluorescence detection, offers high specificity and sensitivity for human samples, making it an essential reagent for immunological studies.CD74, also known as the major histocompatibility complex (MHC) class II-associated invariant chain, plays a pivotal role in antigen processing and presentation to T cells, influencing immune recognition and activation. Its diverse functions in both innate and adaptive immunity highlight its relevance in autoimmune diseases, infectious disorders, and cancer immunotherapy research.

By targeting CD74 with this antibody, researchers can explore its expression, localization, and interactions within various cell types, providing valuable insights into immune regulation mechanisms.With its validated performance in immunofluorescence and flow cytometry applications, the CD74 Monoclonal Antibody (AF488 Conjugated) LN2 (AGEL1058) enables precise visualization and analysis of CD74-expressing cells, facilitating detailed investigations in immunology, oncology, and infectious disease research. This antibody serves as a valuable tool for elucidating the intricate roles of CD74 in immune modulation and disease pathogenesis, advancing our understanding of immune system function and therapeutic strategies.

Product Title:GenieFluor 488 Anti-Human CD74 Antibody [LN2]
SKU:AGEL1058
Size:20 Tests, 100 Tests, 200 Tests
Clone No:LN2
Synonyms:HLA class II histocompatibility antigen gamma chain;CD74;Ia antigen-associated invariant chain;Ii;p33;DHLAG;
Host Species:Mouse
Reactivity:Human
Application:FCM
Isotype:Mouse IgG1, κ
Isotype Control:Genie Fluor 488 Mouse IgG1, κ Isotype Control[MOPC-21]
Form:Liquid
Conjugation:Genie Fluor488
Recommended Use:Each lot of this antibody is quality control tested by flow cytometric analysis. The amount of the reagent is suggested to be used 5 µL of antibody per test (million cells in 100 µL staining volume or per 100 µL of whole blood). Please check your vial before the experiment. Since applications vary, the appropriate dilutions must be determined for individual use.
Spectrum:Spectrum Image
Swissprot:P04233
Gene ID:972
Storage Buffer:Phosphate buffered solution, pH 7.2, containing 0.09% stabilizer and 1% protein protectant.
Stability & Storage:Keep as concentrated solution. Store at 2~8°C and protected from prolonged exposure to light. Do not freeze. Centrifuge before opening to ensure complete recovery of vial contents. This product is guaranteed up to one year from purchase.
Background:CD74 is a type II transmembrane glycoprotein also known as MHC class II associated invariant chain, invariant chain, Ii, MHC class II chaperone, and MIF receptor. CD74 exists in four isoforms with molecular masses of 33, 35, 41, and 43 kD, depending on genetic splicing. CD74 is primarily expressed on antigen presenting cells, including B cells, monocytes/macrophages, dendritic cells, and Langerhans cells. It is also expressed by activated T cells and activated endothelial and epithelial cells as well as carcinomas of lung, renal, gastric and thymic origin. The primary function of CD74 is intracellular sorting of MHC class II molecules and regulation of exogenous peptide loading onto MHC class II. It is also involved in the modulation of B cell differentiation and positive selection of CD4+ T cells. It has been reported that CD74 binds MIF (macrophage migration inhibitory factor) and signals through CD44 to regulate innate and adaptive immunity. It is also reported that H. pylori infection occurs through urease B binding of CD74 on gastric epithelial cells, inducing gastric epithelial cell apoptosis, NF-κB activation, and IL-8 production.

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