Human CD68 Recombinant Protein (RPPB3086)

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SKU:
RPPB3086
Product type:
Recombinant Protein
Size:
5ug
Species:
Human
Target:
CD68
Synonyms:
Macrosialin
Synonyms:
Gp110
Synonyms:
CD68 antigen
Synonyms:
CD68
Source:
Escherichia Coli
Uniprot:
P34810
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Description

Product Name:Human CD68 Recombinant Protein
Product Code:RPPB3086
Size:5µg
Species:Human
Target:CD68
Synonyms:Macrosialin, Gp110, CD68 antigen, CD68, SCARD1, DKFZp686M18236.
Source:Escherichia Coli
Physical Appearance:Sterile Filtered clear solution.
Formulation:CD68 at 100µg/1ml in 50mM Tris-Acetate, pH7.5, 1mM EDTA, 20% Glycerol.
Stability:Store vial at -20°C to -80°C. When stored at the recommended temperature, this protein is stable for 12 months.Please prevent freeze-thaw cycles.

CD68 encodes a 110-kD transmembrane glycoprotein that is highly expressed by human monocytes and tissue macrophages. It is a member of the lysosomal/endosomal-associated membrane glycoprotein (LAMP) family. The protein primarily localizes to lysosomes and endosomes with a smaller fraction circulating to the cell surface. It is a type I integral membrane protein with a heavily glycosylated extracellular domain and binds to tissue- and organ-specific lectins or selectins. The protein is also a member of the scavenger receptor family. Scavenger receptors typically function to clear cellular debris, promote phagocytosis, and mediate the recruitment and activation of macrophages. Alternative splicing results in multiple transcripts encoding different isoforms.

CD68 Human Recombinant full length expressed in E.coli, shows a 38 kDa band on SDS-PAGE.CD68 is purified by proprietary chromatographic techniques.

UniProt Protein Function:CD68: Could play a role in phagocytic activities of tissue macrophages, both in intracellular lysosomal metabolism and extracellular cell-cell and cell-pathogen interactions. Binds to tissue- and organ-specific lectins or selectins, allowing homing of macrophage subsets to particular sites. Rapid recirculation of CD68 from endosomes and lysosomes to the plasma membrane may allow macrophages to crawl over selectin-bearing substrates or other cells. Belongs to the LAMP family. 2 isoforms of the human protein are produced by alternative splicing.
UniProt Protein Details:

Protein type:Cell surface; Membrane protein, integral

Chromosomal Location of Human Ortholog: 17p13

Cellular Component: membrane; lysosomal membrane; plasma membrane; integral to membrane; endosome membrane

NCBI Summary:This gene encodes a 110-kD transmembrane glycoprotein that is highly expressed by human monocytes and tissue macrophages. It is a member of the lysosomal/endosomal-associated membrane glycoprotein (LAMP) family. The protein primarily localizes to lysosomes and endosomes with a smaller fraction circulating to the cell surface. It is a type I integral membrane protein with a heavily glycosylated extracellular domain and binds to tissue- and organ-specific lectins or selectins. The protein is also a member of the scavenger receptor family. Scavenger receptors typically function to clear cellular debris, promote phagocytosis, and mediate the recruitment and activation of macrophages. Alternative splicing results in multiple transcripts encoding different isoforms. [provided by RefSeq, Jul 2008]
UniProt Code:P34810
NCBI GenInfo Identifier:147744552
NCBI Gene ID:968
NCBI Accession:P34810.2
UniProt Secondary Accession:P34810,Q53HR6, Q53XI3, Q96BI7, B4DVT4,
UniProt Related Accession:P34810
Molecular Weight:354
NCBI Full Name:Macrosialin
NCBI Synonym Full Names:CD68 molecule
NCBI Official Symbol:CD68  
NCBI Official Synonym Symbols:GP110; LAMP4; SCARD1  
NCBI Protein Information:macrosialin; CD68 antigen; macrophage antigen CD68; scavenger receptor class D, member 1
UniProt Protein Name:Macrosialin
UniProt Synonym Protein Names:Gp110; CD_antigen: CD68
Protein Family:Macrosialin
UniProt Gene Name:CD68  
UniProt Entry Name:CD68_HUMAN
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