Human CD68 Recombinant Protein (RPPB3085)
- SKU:
- RPPB3085
- Product type:
- Recombinant Protein
- Size:
- 10ug
- Species:
- Human
- Target:
- CD68
- Synonyms:
- Macrosialin
- Gp110
- CD68 antigen
- CD68
- Source:
- Escherichia Coli
- Uniprot:
- P34810
Description
| Product Name: | Human CD68 Recombinant Protein |
| Product Code: | RPPB3085 |
| Size: | 10µg |
| Species: | Human |
| Target: | CD68 |
| Synonyms: | Macrosialin, Gp110, CD68 antigen, CD68, SCARD1, DKFZp686M18236. |
| Source: | Escherichia Coli |
| Physical Appearance: | Sterile Filtered colorless solution. |
| Formulation: | The CD68 solution (1mg/1ml) contains 20mM Tris-HCl buffer (pH 8.0), 0.1M NaCl, 1M Urea and 10% glycerol. |
| Stability: | Store at 4°C if entire vial will be used within 2-4 weeks. Store, frozen at -20°C for longer periods of time. For long term storage it is recommended to add a carrier protein (0.1% HSA or BSA).Avoid multiple freeze-thaw cycles. |
| Purity: | Greater than 85% as determined by SDS-PAGE. |
| Amino Acid Sequence: | MGSSHPLHHH SSGLVPRGSH MGSHMNDCPH KKSATLLPSF TVTPTVTEST GTTSHRTTKS HKTTTHRTTT TGTTSHGPTT ATHNPTTTSH GNVTVHPTSN STATSQGPST ATHSPATTSH GNATVHPTSN STATSPGFTS SAHPEPPPPS PSPSPTSKET IGDYTWTNGS QPCVHLQAQI QIRVMYTTQG GGEAWGISVL NPNKTKVQGS CEGAHPHLLL SFPYGHLSFG FMQDLQQKVV YLSYMAVEYN VSFPHAAQWT FSAQNASLRD LQAPLGQSFS CSNSSIILSP AVHLDLLSLR LQAAQLPHTG VFGQSFSCPS DRS |
CD68 encodes a 110-kD transmembrane glycoprotein that is highly expressed by human monocytes and tissue macrophages. It is a member of the lysosomal/endosomal-associated membrane glycoprotein (LAMP) family. The protein primarily localizes to lysosomes and endosomes with a smaller fraction circulating to the cell surface. It is a type I integral membrane protein with a heavily glycosylated extracellular domain and binds to tissue- and organ-specific lectins or selectins. The protein is also a member of the scavenger receptor family. Scavenger receptors typically function to clear cellular debris, promote phagocytosis, and mediate the recruitment and activation of macrophages. Alternative splicing results in multiple transcripts encoding different isoforms.
CD68 Human Recombinant produced in E. coli is a single polypeptide chain containing 323 amino acids (22-319) and having a molecular mass of 34.1 kDa.CD68 is fused to a 25 amino acid His-tag at N-terminus & purified by proprietary chromatographic techniques.
| UniProt Protein Function: | CD68: Could play a role in phagocytic activities of tissue macrophages, both in intracellular lysosomal metabolism and extracellular cell-cell and cell-pathogen interactions. Binds to tissue- and organ-specific lectins or selectins, allowing homing of macrophage subsets to particular sites. Rapid recirculation of CD68 from endosomes and lysosomes to the plasma membrane may allow macrophages to crawl over selectin-bearing substrates or other cells. Belongs to the LAMP family. 2 isoforms of the human protein are produced by alternative splicing. |
| UniProt Protein Details: | Protein type:Cell surface; Membrane protein, integral Chromosomal Location of Human Ortholog: 17p13 Cellular Component: membrane; lysosomal membrane; plasma membrane; integral to membrane; endosome membrane |
| NCBI Summary: | This gene encodes a 110-kD transmembrane glycoprotein that is highly expressed by human monocytes and tissue macrophages. It is a member of the lysosomal/endosomal-associated membrane glycoprotein (LAMP) family. The protein primarily localizes to lysosomes and endosomes with a smaller fraction circulating to the cell surface. It is a type I integral membrane protein with a heavily glycosylated extracellular domain and binds to tissue- and organ-specific lectins or selectins. The protein is also a member of the scavenger receptor family. Scavenger receptors typically function to clear cellular debris, promote phagocytosis, and mediate the recruitment and activation of macrophages. Alternative splicing results in multiple transcripts encoding different isoforms. [provided by RefSeq, Jul 2008] |
| UniProt Code: | P34810 |
| NCBI GenInfo Identifier: | 147744552 |
| NCBI Gene ID: | 968 |
| NCBI Accession: | P34810.2 |
| UniProt Secondary Accession: | P34810,Q53HR6, Q53XI3, Q96BI7, B4DVT4, |
| UniProt Related Accession: | P34810 |
| Molecular Weight: | 354 |
| NCBI Full Name: | Macrosialin |
| NCBI Synonym Full Names: | CD68 molecule |
| NCBI Official Symbol: | CD68 |
| NCBI Official Synonym Symbols: | GP110; LAMP4; SCARD1 |
| NCBI Protein Information: | macrosialin; CD68 antigen; macrophage antigen CD68; scavenger receptor class D, member 1 |
| UniProt Protein Name: | Macrosialin |
| UniProt Synonym Protein Names: | Gp110; CD_antigen: CD68 |
| Protein Family: | Macrosialin |
| UniProt Gene Name: | CD68 |
| UniProt Entry Name: | CD68_HUMAN |
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