APC Anti-Human CD61 Antibody [VI-PL2] (AGEL1827)

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SKU:
AGEL1827
Product Type:
Antibody
Antibody Type:
Monoclonal Antibody
Reactivity:
Human
Applications:
FC
Frequently bought together:

Description

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APC Anti-Human CD61 Antibody [VI-PL2]

The Human CD61 Monoclonal Antibody (APC Conjugated) is an essential tool for researchers studying CD61, a key cell surface glycoprotein involved in platelet aggregation and adhesion. This monoclonal antibody, conjugated with APC for fluorescence-based applications, offers high specificity and sensitivity when detecting CD61 in human samples. Validated for use in flow cytometry and other immunological assays, this antibody binds specifically to CD61, enabling precise analysis of its expression in various cell types.CD61, also known as integrin beta-3, plays a crucial role in platelet function and thrombus formation, making it a significant target for investigations in hematology, cardiovascular research, and thrombosis studies.

Understanding the expression and function of CD61 is vital in elucidating its role in platelet physiology and pathophysiology, paving the way for potential therapeutic interventions in conditions such as thrombocytopenia, cardiovascular diseases, and bleeding disorders.Researchers can leverage the Human CD61 Monoclonal Antibody (APC Conjugated) to explore the intricacies of CD61-mediated processes and advance our understanding of platelet biology, hemostasis, and vascular integrity. By utilizing this antibody, scientists can delve deeper into the molecular mechanisms underlying platelet function and potentially uncover new strategies for managing platelet-related disorders.

Product Title:APC Anti-Human CD61 Antibody [VI-PL2]
SKU:AGEL1827
Size:20 Tests, 100 Tests, 200 Tests
Clone No:VI-PL2
Synonyms:GP3A;GPIIIa;ITGB3;Integrin beta-3;
Host Species:Mouse
Reactivity:Human
Application:FCM
Isotype:Mouse IgG1, κ
Isotype Control:APC Mouse IgG1, κ Isotype Control[MOPC-21]
Form:Liquid
Conjugation:APC
Recommended Use:Each lot of this antibody is quality control tested by flow cytometric analysis. The amount of the reagent is suggested to be used 5 µL of antibody per test (million cells in 100 µL staining volume or per 100 µL of whole blood). Please check your vial before the experiment. Since applications vary, the appropriate dilutions must be determined for individual use.
Spectrum:Spectrum Image
Swissprot:P05106
Gene ID:3690
Storage Buffer:Phosphate buffered solution, pH 7.2, containing 0.09% stabilizer and 1% protein protectant.
Stability & Storage:Keep as concentrated solution. Store at 2~8°C and protected from prolonged exposure to light. Do not freeze. Centrifuge before opening to ensure complete recovery of vial contents. This product is guaranteed up to one year from purchase.
Background:CD61, also known as integrin β3 and glycoprotein IIIa (gpIIIa), is a 90 kD type I integral transmembrane glycoprotein. It is a member of the integrin family, associating with platelet gpIIb (CD41) to form CD41/CD61 complex and with integrin αV (CD51) to form αV/β3 (CD51/CD61) integrin. CD41/CD61 is expressed on platelets and megakaryocytes, and plays a role in platelet activation and aggregation through interaction with fibrinogen, fibronectin, vWF, and other RGD-containing adhesion molecules. CD51/CD61 is expressed on platelets, osteoclasts, fibroblasts, macrophages, and some tumor cells involved in tumor metastasis, and in adenovirus infection through binding to RGD motif in extracellular matrix proteins.

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