The Human CD58 Monoclonal Antibody (PE/Cyanine7 Conjugated, TS2/9.1) - AGEL1041 is a cutting-edge tool for researchers studying CD58, a cell surface glycoprotein involved in immune responses. This antibody, specifically engineered for human samples, is expertly conjugated with PE/Cyanine7 for enhanced detection capabilities. With its high specificity and sensitivity, this antibody is ideal for flow cytometry applications, enabling precise analysis of CD58 expression levels in various cell types.CD58, also known as LFA-3, plays a crucial role in T cell activation and adhesion processes by interacting with CD2 on T cells. Its importance in immune cell communication and regulation makes it a valuable target for research in immunology, transplantation, and infectious diseases.
The Human CD58 Monoclonal Antibody facilitates the investigation of CD58-mediated immune interactions, providing valuable insights into immune signaling pathways and potential therapeutic targets.Researchers interested in understanding the intricate mechanisms of immune cell communication and modulation will find the Human CD58 Monoclonal Antibody (PE/Cyanine7 Conjugated, TS2/9.1) - AGEL1041 to be a valuable asset in their studies. Its reliability, specificity, and versatility make it a pivotal tool for unraveling the complexities of immune responses and developing targeted interventions for various immune-related conditions.
Each lot of this antibody is quality control tested by flow cytometric analysis. The amount of the reagent is suggested to be used 5 µL of antibody per test (million cells in 100 µL staining volume or per 100 µL of whole blood). Please check your vial before the experiment. Since applications vary, the appropriate dilutions must be determined for individual use.
Spectrum:
Swissprot:
P19256
Gene ID:
965
Storage Buffer:
Phosphate buffered solution, pH 7.2, containing 0.09% stabilizer and 1% protein protectant.
Stability & Storage:
Keep as concentrated solution. Store at 2~8°C and protected from prolonged exposure to light. Do not freeze. Centrifuge before opening to ensure complete recovery of vial contents. This product is guaranteed up to one year from purchase.
Background:
CD58, also known as lymphocyte function-associated antigen 3 (LFA-3) is a 45-70 kD cell surface protein that is a member of the immunoglobulin superfamily. Alternative splicing of CD58 gives rise to transmembrane and glycosylphosphatidylinositol (GPI)-anchored forms on cell surface. CD58 is expressed on both hematopoietic and non-hematopoietic cells including B cells, T cells, monocytes, erythrocytes, endothelial cells, epithelial cells, and fibroblasts. High levels are observed on memory T cells and dendritic cells. CD58 expressed on antigen presenting cells and target cells enhances T cell recognition via the binding of it's cognate ligand, CD2, on the T cell surface.