Human CD5 Recombinant Protein (RPPB3021)

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SKU:
RPPB3021
Product type:
Recombinant Protein
Size:
10ug
Species:
Human
Target:
CD5
Synonyms:
CD5 Molecule
Synonyms:
Lymphocyte Antigen T1/Leu-1
Synonyms:
CD5 Antigen (P56-62)
Synonyms:
LEU1
Source:
Sf9 Insect cells
Uniprot:
P06127
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Description

Product Name:Human CD5 Recombinant Protein
Product Code:RPPB3021
Size:10µg
Species:Human
Target:CD5
Synonyms:CD5 Molecule, Lymphocyte Antigen T1/Leu-1, CD5 Antigen (P56-62), LEU1, T-Cell Surface Glycoprotein CD5, CD5 Antigen, T1.
Source:Sf9 Insect cells
Physical Appearance:Sterile filtered colorless solution.
Formulation:CD5 protein solution (0.5mg/ml) contains Phosphate buffered saline (pH7.4) and 10% glycerol.
Stability:Store at 4°C if entire vial will be used within 2-4 weeks. Store, frozen at -20°C for longer periods of time. For long term storage it is recommended to add a carrier protein (0.1% HSA or BSA).Avoid multiple freeze-thaw cycles.
Purity:Greater than 95.0% as determined by SDS-PAGE.
Amino Acid Sequence:ADPEFRLSWY DPDFQARLTR SNSKCQGQLE VYLKDGWHMV CSQSWGRSSK QWEDPSQASK VCQRLNCGVP LSLGPFLVTY TPQSSIICYG QLGSFSNCSH SRNDMCHSLG LTCLEPQKTT PPTTRPPPTT TPEPTAPPRL QLVAQSGGQH CAGVVEFYSG SLGGTISYEA QDKTQDLENF LCNNLQCGSF LKHLPETEAG RAQDPGEPRE HQPLPIQWKI QNSSCTSLEH CFRKIKPQKS GRVLALLCSG FQPKVQSRLV GGSSICEGTV EVRQGAQWAA LCDSSSARSS LRWEEVCREQ QCGSVNSYRV LDAGDPTSRG LFCPHQKLSQ CHELWERNSY CKKVFVTCQD PNPHHHHHH

CD5 is a suitable immunohistochemical marker for T-cells, though not as sensitive as CD3. Approximately 76% of T-cell neoplasms are reported to express CD5, and it is also observed in chronic lymphocytic leukemia, hairy cell leukemia, and mantle cell lymphoma cells. CD5 is commonly lost in cutaneous T-cell lymphoma, and its deficiency can be used as an indicator of malignancy in this condition. CD5’s absence in T cell acute lymphoblastic leukemia, though relatively rare, is linked with a poor prognosis. CD5 serves as a receptor in regulating T-cell proliferation.

CD5 Human Recombinant produced in Sf9 Baculovirus cells is a single, glycosylated polypeptide chain containing 359 amino acids (25-372a.a.) and having a molecular mass of 40kDa (Molecular size on SDS-PAGE will appear at approximately 40-57 kDa). CD5 is expressed with a 6 amino acids His tag at C-Terminus and purified by proprietary chromatographic techniques.

UniProt Protein Function:CD5: a surface glycoprotein expressed on T cells and B-1 B cells. Rapidly recruited to the immunological synapse, lowering the response of the T cell antigen receptor. CD5 interacts with CD72/LYB-2. Promotes B-cell survival through stimulation of autocrine IL-10 production. Contains 3 SRCR domains.
UniProt Protein Details:

Protein type:Cell surface; Membrane protein, integral

Chromosomal Location of Human Ortholog: 11q13

Cellular Component: integral to plasma membrane; plasma membrane; external side of plasma membrane

Molecular Function:protein binding; transmembrane receptor activity; receptor activity; scavenger receptor activity

Biological Process: cell proliferation; receptor-mediated endocytosis; T cell costimulation; cell recognition

UniProt Code:P06127
NCBI GenInfo Identifier:313104090
NCBI Gene ID:921
NCBI Accession:P06127.2
UniProt Secondary Accession:P06127,A0N0P4, A8K9I3,
UniProt Related Accession:P06127
Molecular Weight:459
NCBI Full Name:T-cell surface glycoprotein CD5
NCBI Synonym Full Names:CD5 molecule
NCBI Official Symbol:CD5  
NCBI Official Synonym Symbols:T1; LEU1  
NCBI Protein Information:T-cell surface glycoprotein CD5; CD5 antigen (p56-62); lymphocyte antigen T1/Leu-1
UniProt Protein Name:T-cell surface glycoprotein CD5
UniProt Synonym Protein Names:Lymphocyte antigen T1/Leu-1; CD_antigen: CD5
Protein Family:CD5 antigen
UniProt Gene Name:CD5  
UniProt Entry Name:CD5_HUMAN
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