Human CD5 Recombinant Protein (RPPB3020)
- SKU:
- RPPB3020
- Product type:
- Recombinant Protein
- Size:
- 20ug
- Species:
- Human
- Target:
- CD5
- Synonyms:
- CD5 Molecule
- CD5
- LEU1
- CD5 Antigen (P56-62)
- Source:
- Escherichia Coli
- Uniprot:
- P06127
Description
| Product Name: | Human CD5 Recombinant Protein |
| Product Code: | RPPB3020 |
| Size: | 20µg |
| Species: | Human |
| Target: | CD5 |
| Synonyms: | CD5 Molecule, CD5, LEU1, CD5 Antigen (P56-62), Lymphocyte Antigen T1/Leu-1, T1, T-Cell Surface Glycoprotein CD5, CD5 Antigen. |
| Source: | Escherichia Coli |
| Physical Appearance: | Sterile Filtered colorless solution. |
| Formulation: | The CD5 solution (1mg/ml) contains 20mM Tris-HCl buffer (pH8.0), 10% glycerol and 0.4M Urea. |
| Stability: | Store at 4°C if entire vial will be used within 2-4 weeks. Store, frozen at -20°C for longer periods of time. For long term storage it is recommended to add a carrier protein (0.1% HSA or BSA).Avoid multiple freeze-thaw cycles. |
| Purity: | Greater than 80% as determined by SDS-PAGE. |
| Amino Acid Sequence: | MGSSHHHHHH SSGLVPRGSH MGSRLSWYDP DFQARLTRSN SKCQGQLEVY LKDGWHMVCS QSWGRSSKQW EDPSQASKVC QRLNCGVPLS LGPFLVTYTP QSSIICYGQL GSFSNCSHSR NDMCHSLGLT CLEPQKTTPP TTRPPPTTTP EPTAPPRLQL VAQSGGQHCA GVVEFYSGSL GGTISYEAQD KTQDLENFLC NNLQCGSFLK HLPETEAGRA QDPGEPREHQ PLPIQWKIQN SSCTSLEHCF RKIKPQKSGR VLALLCSGFQ PKVQSRLVGG SSICEGTVEV RQGAQWAALC DSSSARSSLR WEEVCREQQC GSVNSYRVLD AGDPTSRGLF CPHQKLSQCH ELWERNSYCK KVFVTCQDPN P |
CD5 is a suitable immunohistochemical marker for T-cells, though not as sensitive as CD3. Approximately 76% of T-cell neoplasms are reported to express CD5, and it is also observed in chronic lymphocytic leukemia, hairy cell leukemia, and mantle cell lymphoma cells. CD5 is commonly lost in cutaneous T-cell lymphoma, and its deficiency can be used as an indicator of malignancy in this condition. CD5’s absence in T cell acute lymphoblastic leukemia, though relatively rare, is linked with a poor prognosis. CD5 serves as a receptor in regulating T-cell proliferation.
CD5 Human Recombinant produced in E.coli is a single, non-glycosylated polypeptide chain containing 371 amino acids (25-372) and having a molecular mass of 41.0 kDa.CD5 is fused to a 23 amino acid His-tag at N-terminus & purified by proprietary chromatographic techniques.
| UniProt Protein Function: | CD5: a surface glycoprotein expressed on T cells and B-1 B cells. Rapidly recruited to the immunological synapse, lowering the response of the T cell antigen receptor. CD5 interacts with CD72/LYB-2. Promotes B-cell survival through stimulation of autocrine IL-10 production. Contains 3 SRCR domains. |
| UniProt Protein Details: | Protein type:Cell surface; Membrane protein, integral Chromosomal Location of Human Ortholog: 11q13 Cellular Component: integral to plasma membrane; plasma membrane; external side of plasma membrane Molecular Function:protein binding; transmembrane receptor activity; receptor activity; scavenger receptor activity Biological Process: cell proliferation; receptor-mediated endocytosis; T cell costimulation; cell recognition |
| UniProt Code: | P06127 |
| NCBI GenInfo Identifier: | 313104090 |
| NCBI Gene ID: | 921 |
| NCBI Accession: | P06127.2 |
| UniProt Secondary Accession: | P06127,A0N0P4, A8K9I3, |
| UniProt Related Accession: | P06127 |
| Molecular Weight: | 459 |
| NCBI Full Name: | T-cell surface glycoprotein CD5 |
| NCBI Synonym Full Names: | CD5 molecule |
| NCBI Official Symbol: | CD5 |
| NCBI Official Synonym Symbols: | T1; LEU1 |
| NCBI Protein Information: | T-cell surface glycoprotein CD5; CD5 antigen (p56-62); lymphocyte antigen T1/Leu-1 |
| UniProt Protein Name: | T-cell surface glycoprotein CD5 |
| UniProt Synonym Protein Names: | Lymphocyte antigen T1/Leu-1; CD_antigen: CD5 |
| Protein Family: | CD5 antigen |
| UniProt Gene Name: | CD5 |
| UniProt Entry Name: | CD5_HUMAN |
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