PE/Cyanine5 Anti-Human CD49d Antibody [9F10] (AGEL1740)

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SKU:
AGEL1740
Product Type:
Antibody
Antibody Type:
Monoclonal Antibody
Reactivity:
Human
Applications:
FC
Frequently bought together:

Description

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PE/Cyanine5 Anti-Human CD49d Antibody [9F10]

The Human CD49d Monoclonal Antibody PE-Cyanine5 Conjugated (9F10) is a cutting-edge tool for researchers studying CD49d, a key integrin involved in cell adhesion and migration processes. This monoclonal antibody, conjugated with PE-Cyanine5 for enhanced detection capabilities, is specifically designed for use in flow cytometry applications, enabling precise identification and analysis of CD49d-expressing cells.CD49d, also known as integrin alpha-4, plays a crucial role in mediating cell-cell and cell-matrix interactions, making it critical for processes like immune cell trafficking, tissue inflammation, and tumor metastasis. Understanding the function and expression of CD49d is essential for unraveling its implications in various biological processes and diseases.

By utilizing this highly specific monoclonal antibody, researchers can gain valuable insights into the role of CD49d in immunology, cancer biology, and beyond.With its validated performance in flow cytometry and compatibility with human samples, the Human CD49d Monoclonal Antibody PE-Cyanine5 Conjugated (9F10) is a reliable tool for advancing research in cell adhesion, migration, and disease mechanisms associated with CD49d. Invest in this antibody to unlock new possibilities in your studies and contribute to the advancement of scientific knowledge in integrin biology.

Product Title:PE/Cyanine5 Anti-Human CD49d Antibody [9F10]
SKU:AGEL1740
Size:20 Tests, 100 Tests, 200 Tests
Clone No:9F10
Synonyms:Integrin alpha-4;CD49 antigen-like family member D;Integrin alpha-IV;VLA-4 subunit alpha;CD49d;ITGA4;
Host Species:Mouse
Reactivity:Human
Application:FCM
Isotype:Mouse IgG1, κ
Form:Liquid
Conjugation:PE/Cyanine 5
Recommended Use:Each lot of this antibody is quality control tested by flow cytometric analysis. The amount of the reagent is suggested to be used 5 µL of antibody per test (million cells in 100 µL staining volume or per 100 µL of whole blood). Please check your vial before the experiment. Since applications vary, the appropriate dilutions must be determined for individual use.
Spectrum:Spectrum Image
Swissprot:P13612
Gene ID:3676
Storage Buffer:Phosphate buffered solution, pH 7.2, containing 0.09% stabilizer and 1% protein protectant.
Stability & Storage:Keep as concentrated solution. Store at 2~8°C and protected from prolonged exposure to light. Do not freeze. Centrifuge before opening to ensure complete recovery of vial contents. This product is guaranteed up to one year from purchase.
Background:CD49d is a 150 kD α integrin chain known as α4 integrin or VLA-4 α chain. It forms a heterodimer with either integrin β1 (α4β1, VLA-4) or β7 (α4β7). CD49d is expressed broadly on T lymphocytes, B lymphocytes, monocytes, thymocytes, eosinophils, basophils, mast cells, NK cells, dendritic cells, and some non-hematopoietic cells, but not on normal red blood cells, platelets or neutrophils. VLA-4 binds to VCAM-1 (CD106) and fibronectin. α4β7 is the receptor for VCAM-1 and MAdCAM-1. CD49d participates in mononuclear cell trafficking to endothelial sites of inflammation and has roles in cell-cell interactions and cell adhesion to extracellular matrices. CD49d is involved in lymphocyte migration, T cell activation, and hematopoietic stem cell differentiation. CD49d is a marker to isolate pure populations of Treg cells due to its absence on Foxp3+ cells.

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