PE/Cyanine7 Anti-Human CD47 Antibody [CC2C6D4] (AGEL0996)

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SKU:
AGEL0996
Product Type:
Antibody
Antibody Type:
Monoclonal Antibody
Applications:
FC
Reactivity:
Human
Host Species:
Mouse
Isotype:
IgG2a,k
Clone:
CC2C6D4
Conjugation:
PE/Cy7
Frequently bought together:

Description

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PE/Cyanine7 Anti-Human CD47 Antibody [CC2C6D4]

The Human CD47 Monoclonal Antibody PE-Cyanine7 Conjugated (CC2C6D4) is a valuable tool for researchers interested in studying CD47, a cell surface protein involved in immune modulation and cancer biology. This monoclonal antibody, conjugated with PE-Cyanine7, is specifically designed for flow cytometry applications, enabling precise detection and analysis of CD47 expression on various cell types.CD47, also known as integrin-associated protein, plays a crucial role in immune evasion and regulation of cell signaling pathways. Its interaction with signal regulatory protein alpha (SIRPα) serves as a "don't eat me" signal to phagocytic cells, allowing cancer cells to evade destruction by the immune system.

Understanding the mechanisms by which CD47 influences immune responses is essential for developing targeted therapies for cancer and other diseases.This CD47 monoclonal antibody offers high specificity and sensitivity, making it a reliable tool for investigating the role of CD47 in tumor immune evasion, immune checkpoint blockade, and immunotherapy development. Its conjugation with PE-Cyanine7 facilitates multiplex flow cytometry experiments, enhancing research capabilities in the fields of immunology, oncology, and drug development.

Product Title:PE/Cyanine7 Anti-Human CD47 Antibody [CC2C6D4]
SKU:AGEL0996
Size:20 Tests, 100 Tests, 200 Tests
Clone No:CC2C6D4
Synonyms:Leukocyte surface antigen CD47;Cd47;Integrin-associated protein;IAP;
Host Species:Mouse
Reactivity:Human
Application:FCM
Isotype:Mouse IgG1, κ
Isotype Control:PE/Cyanine7 Mouse IgG1, κ Isotype Control[MOPC-21]
Form:Liquid
Conjugation:PE/Cyanine 7
Recommended Use:Each lot of this antibody is quality control tested by flow cytometric analysis. The amount of the reagent is suggested to be used 5 µL of antibody per test (million cells in 100 µL staining volume or per 100 µL of whole blood). Please check your vial before the experiment. Since applications vary, the appropriate dilutions must be determined for individual use.
Spectrum:Spectrum Image
Swissprot:Q08722
Gene ID:961
Storage Buffer:Phosphate buffered solution, pH 7.2, containing 0.09% stabilizer and 1% protein protectant.
Stability & Storage:Keep as concentrated solution. Store at 2~8°C and protected from prolonged exposure to light. Do not freeze. Centrifuge before opening to ensure complete recovery of vial contents. This product is guaranteed up to one year from purchase.
Background:CD47 also known as Rh-associated protein, gp42, integrin-associated protein (IAP), and neurophilin, is a 42-52 kD member of the immunoglobulin superfamily containing a five-pass transmembrane attachment. Two splice variants have been described in the cytoplasmic tail, the shorter form is expressed in bone-marrow-derived cells, endothelial cells, and fibroblasts while the longer form is expressed by neural tissues. CD47 expression is widely distributed in hematopoietic cells including thymocytes, T cells, B cells, monocytes, platelets, and erythrocytes as well as epithelial cells, endothelial cells, fibroblasts, and neural tissues. CD47 functions as an adhesion molecule and thrombospondin receptor and is non-covalently associated with β3 integrins CD51/CD61, CD41/CD61. Thrombospondin is a ligand for CD47; in the absence of CD47 mice show defects in host defense and β3 integrin-dependent ligand binding, migration, and cellular activation. CD47 is also part of the Rh complex on erythrocytes.

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