PE/Cyanine5.5 Anti-Human CD47 Antibody [CC2C6D4] (AGEL0997)

(No reviews yet) Write a Review
SKU:
AGEL0997
Product Type:
Antibody
Antibody Type:
Monoclonal Antibody
Reactivity:
Human
Applications:
FC
Frequently bought together:

Description

system_update_altDatasheetsystem_update_altMSDS

PE/Cyanine5.5 Anti-Human CD47 Antibody [CC2C6D4]

The Human CD47 Monoclonal Antibody PE/Cyanine5.5 Conjugated (CC2C6D4) is a valuable tool for research involving CD47, a cell surface protein involved in immune regulation and cancer biology. This monoclonal antibody, conjugated with PE/Cyanine5.5, is highly specific for human CD47 and is validated for use in flow cytometry and immunofluorescence applications.CD47, also known as integrin-associated protein, plays a crucial role in immune modulation by interacting with various receptors on immune cells. Its overexpression in cancer cells has been linked to immune evasion and tumor progression, making it a promising target for cancer therapy.

This conjugated antibody enables the detection and analysis of CD47 expression in different cell populations, allowing for further investigation into its role in cancer and immune regulation.Studies using this monoclonal antibody can provide valuable insights into the mechanisms by which CD47 modulates immune responses and contributes to disease progression. Its versatility and specificity make it an essential tool for researchers studying immunology, cancer biology, and related fields.

Product Title:PE/Cyanine5.5 Anti-Human CD47 Antibody [CC2C6D4]
SKU:AGEL0997
Size:20 Tests, 100 Tests, 200 Tests
Clone No:CC2C6D4
Synonyms:Leukocyte surface antigen CD47;Cd47;Integrin-associated protein;IAP;
Host Species:Mouse
Reactivity:Human
Application:FCM
Isotype:Mouse IgG1, κ
Isotype Control:PE/Cyanine5.5 Mouse IgG1, κ Isotype Control[MOPC-21]
Form:Liquid
Conjugation:PE/Cyanine 5.5
Recommended Use:Each lot of this antibody is quality control tested by flow cytometric analysis. The amount of the reagent is suggested to be used 5 µL of antibody per test (million cells in 100 µL staining volume or per 100 µL of whole blood). Please check your vial before the experiment. Since applications vary, the appropriate dilutions must be determined for individual use.
Spectrum:Spectrum Image
Swissprot:Q08722
Gene ID:961
Storage Buffer:Phosphate buffered solution, pH 7.2, containing 0.09% stabilizer and 1% protein protectant.
Stability & Storage:Keep as concentrated solution. Store at 2~8°C and protected from prolonged exposure to light. Do not freeze. Centrifuge before opening to ensure complete recovery of vial contents. This product is guaranteed up to one year from purchase.
Background:CD47 also known as Rh-associated protein, gp42, integrin-associated protein (IAP), and neurophilin, is a 42-52 kD member of the immunoglobulin superfamily containing a five-pass transmembrane attachment. Two splice variants have been described in the cytoplasmic tail, the shorter form is expressed in bone-marrow-derived cells, endothelial cells, and fibroblasts while the longer form is expressed by neural tissues. CD47 expression is widely distributed in hematopoietic cells including thymocytes, T cells, B cells, monocytes, platelets, and erythrocytes as well as epithelial cells, endothelial cells, fibroblasts, and neural tissues. CD47 functions as an adhesion molecule and thrombospondin receptor and is non-covalently associated with β3 integrins CD51/CD61, CD41/CD61. Thrombospondin is a ligand for CD47; in the absence of CD47 mice show defects in host defense and β3 integrin-dependent ligand binding, migration, and cellular activation. CD47 is also part of the Rh complex on erythrocytes.

0 Reviews

View AllClose

Related Products