APC Anti-Human CD47 Antibody [CC2C6D4] (AGEL0253)

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SKU:
AGEL0253
Product Type:
Antibody
Antibody Type:
Monoclonal Antibody
Reactivity:
Human
Host Species:
Mouse
Isotype:
IgG1
Clone:
CC2C6D4
Conjugation:
APC
Applications:
FC
Frequently bought together:

Description

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APC Anti-Human CD47 Antibody [CC2C6D4]

The Human CD47 Monoclonal Antibody (APC Conjugated) (CC2C6D4) is a valuable tool for researchers studying CD47, a cell surface protein involved in immune regulation and cell recognition processes. This monoclonal antibody, produced using cutting-edge technology, specifically targets the CD47 protein in human samples and is validated for use in flow cytometry applications. By binding to CD47, this antibody enables precise detection and analysis of CD47 expression in various cell types, making it ideal for investigations in immunology, cancer research, and beyond.CD47, known for its role in regulating immune responses and phagocytosis, is a key player in the innate immune system. Its interactions with other proteins play a crucial role in modulating immune signaling and determining cellular outcomes.

Research into CD47 has provided insights into its involvement in diseases such as cancer, atherosclerosis, and autoimmune disorders. Understanding the function of CD47 is essential for developing targeted therapies that manipulate immune responses to combat these conditions effectively.In conclusion, the Human CD47 Monoclonal Antibody (APC Conjugated) (CC2C6D4) is a highly specific and reliable tool for investigating the role of CD47 in various biological processes. Its use in flow cytometry experiments allows researchers to explore the functions of CD47 in different cellular contexts, shedding light on its potential as a therapeutic target for various diseases.

Product Title:APC Anti-Human CD47 Antibody [CC2C6D4]
SKU:AGEL0253
Size:20 Tests, 100 Tests, 200 Tests
Clone No:CC2C6D4
Synonyms:Leukocyte surface antigen CD47;Cd47;Integrin-associated protein;IAP;
Host Species:Mouse
Reactivity:Human
Application:FCM
Isotype:Mouse IgG1, κ
Isotype Control:APC Mouse IgG1, κ Isotype Control[MOPC-21]
Form:Liquid
Conjugation:APC
Recommended Use:Each lot of this antibody is quality control tested by flow cytometric analysis. The amount of the reagent is suggested to be used 5 µL of antibody per test (million cells in 100 µL staining volume or per 100 µL of whole blood). Please check your vial before the experiment. Since applications vary, the appropriate dilutions must be determined for individual use.
Spectrum:Spectrum Image
Swissprot:Q08722
Gene ID:961
Storage Buffer:Phosphate buffered solution, pH 7.2, containing 0.09% stabilizer and 1% protein protectant.
Stability & Storage:Keep as concentrated solution. Store at 2~8°C and protected from prolonged exposure to light. Do not freeze. Centrifuge before opening to ensure complete recovery of vial contents. This product is guaranteed up to one year from purchase.
Background:CD47 also known as Rh-associated protein, gp42, integrin-associated protein (IAP), and neurophilin, is a 42-52 kD member of the immunoglobulin superfamily containing a five-pass transmembrane attachment. Two splice variants have been described in the cytoplasmic tail, the shorter form is expressed in bone-marrow-derived cells, endothelial cells, and fibroblasts while the longer form is expressed by neural tissues. CD47 expression is widely distributed in hematopoietic cells including thymocytes, T cells, B cells, monocytes, platelets, and erythrocytes as well as epithelial cells, endothelial cells, fibroblasts, and neural tissues. CD47 functions as an adhesion molecule and thrombospondin receptor and is non-covalently associated with β3 integrins CD51/CD61, CD41/CD61. Thrombospondin is a ligand for CD47; in the absence of CD47 mice show defects in host defense and β3 integrin-dependent ligand binding, migration, and cellular activation. CD47 is also part of the Rh complex on erythrocytes.

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