GenieFluor 488 Anti-Human CD47 Antibody [CC2C6D4] (AGEL0254)

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SKU:
AGEL0254
Product Type:
Antibody
Antibody Type:
Monoclonal Antibody
Reactivity:
Human
Host Species:
Mouse
Isotype:
IgG1
Clone:
CC2C6D4
Conjugation:
AF 488
Applications:
FC
Frequently bought together:

Description

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GenieFluor 488 Anti-Human CD47 Antibody [CC2C6D4]

The Human CD47 Monoclonal Antibody (Alexa Fluor 488 Conjugated) is a cutting-edge tool for researchers investigating the CD47 protein, a versatile molecule involved in immune response modulation and cancer development. This monoclonal antibody, labeled with Alexa Fluor 488 for efficient detection and visualization, specifically targets human CD47 for precise analysis in a variety of cell types.CD47, also known as integrin-associated protein, plays a multifaceted role in both normal physiological processes and pathological conditions such as cancer. Its interaction with the signal regulatory protein alpha (SIRPα) allows for immune evasion of cancer cells and regulation of phagocytosis.

The Human CD47 Monoclonal Antibody provides researchers with a reliable method to explore the functions of CD47 in immune regulation, tumor development, and potential therapeutic targeting.Ideal for use in immunology, oncology, and biotechnology research, this antibody offers high specificity and sensitivity in techniques such as immunofluorescence, flow cytometry, and immunohistochemistry. By facilitating the precise detection and analysis of CD47 expression and localization, this antibody empowers scientists to deepen their understanding of immune evasion mechanisms in cancer and explore novel approaches for anti-cancer therapy development.

Product Title:GenieFluor 488 Anti-Human CD47 Antibody [CC2C6D4]
SKU:AGEL0254
Size:20 Tests, 100 Tests, 200 Tests
Clone No:CC2C6D4
Synonyms:Leukocyte surface antigen CD47;Cd47;Integrin-associated protein;IAP;
Host Species:Mouse
Reactivity:Human
Application:FCM
Isotype:Mouse IgG1, κ
Isotype Control:Genie Fluor 488 Mouse IgG1, κ Isotype Control[MOPC-21]
Form:Liquid
Conjugation:Genie Fluor488
Recommended Use:Each lot of this antibody is quality control tested by flow cytometric analysis. The amount of the reagent is suggested to be used 5 µL of antibody per test (million cells in 100 µL staining volume or per 100 µL of whole blood). Please check your vial before the experiment. Since applications vary, the appropriate dilutions must be determined for individual use.
Spectrum:Spectrum Image
Swissprot:Q08722
Gene ID:961
Storage Buffer:Phosphate buffered solution, pH 7.2, containing 0.09% stabilizer and 1% protein protectant.
Stability & Storage:Keep as concentrated solution. Store at 2~8°C and protected from prolonged exposure to light. Do not freeze. Centrifuge before opening to ensure complete recovery of vial contents. This product is guaranteed up to one year from purchase.
Background:CD47 also known as Rh-associated protein, gp42, integrin-associated protein (IAP), and neurophilin, is a 42-52 kD member of the immunoglobulin superfamily containing a five-pass transmembrane attachment. Two splice variants have been described in the cytoplasmic tail, the shorter form is expressed in bone-marrow-derived cells, endothelial cells, and fibroblasts while the longer form is expressed by neural tissues. CD47 expression is widely distributed in hematopoietic cells including thymocytes, T cells, B cells, monocytes, platelets, and erythrocytes as well as epithelial cells, endothelial cells, fibroblasts, and neural tissues. CD47 functions as an adhesion molecule and thrombospondin receptor and is non-covalently associated with β3 integrins CD51/CD61, CD41/CD61. Thrombospondin is a ligand for CD47; in the absence of CD47 mice show defects in host defense and β3 integrin-dependent ligand binding, migration, and cellular activation. CD47 is also part of the Rh complex on erythrocytes.

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