The Human CD45RA Monoclonal Antibody (PERCP-Cyanine5.5 Conjugated, HI100) is a powerful tool for research in immunology and cell biology. This antibody, designated AGEL0960, specifically targets the CD45RA antigen, a marker found on subsets of T cells and B cells that play a key role in the immune response.Developed for precision and reliability, this monoclonal antibody is conjugated with PERCP-Cyanine5.5 to enable efficient detection and analysis of CD45RA-expressing cells by flow cytometry. It offers high sensitivity and specificity, making it ideal for identifying and characterizing immune cell populations in various experimental settings.The CD45RA antigen is crucial for distinguishing naive T cells from memory T cells, providing valuable insights into the immune status and responsiveness of an individual.
By targeting CD45RA with this monoclonal antibody, researchers can delve deeper into the dynamics of immune cell populations, aiding in studies related to immune system development, activation, and dysfunction.With its high reactivity and validated performance in flow cytometry applications, the Human CD45RA Monoclonal Antibody (PERCP-Cyanine5.5 Conjugated, HI100) is a valuable asset for researchers exploring immunology, vaccine development, and immune-mediated diseases. Unleash the power of precise immune cell analysis with this exceptional antibody.
Each lot of this antibody is quality control tested by flow cytometric analysis. The amount of the reagent is suggested to be used 5 µL of antibody per test (million cells in 100 µL staining volume or per 100 µL of whole blood). Please check your vial before the experiment. Since applications vary, the appropriate dilutions must be determined for individual use.
Spectrum:
Swissprot:
P08575
Gene ID:
5788
Storage Buffer:
Phosphate buffered solution, pH 7.2, containing 0.09% stabilizer and 1% protein protectant.
Stability & Storage:
Keep as concentrated solution. Store at 2~8°C and protected from prolonged exposure to light. Do not freeze. Centrifuge before opening to ensure complete recovery of vial contents. This product is guaranteed up to one year from purchase.
Background:
CD45RA is a 205-220 kD single chain type I glycoprotein. It is an exon 4 splice variant of the tyrosine phosphatase CD45. The CD45RA isoform is expressed on resting/naïve T cells, medullary thymocytes, B cells and monocytes. CD45RA enhances both T cell receptor and B cell receptor signaling. CD45 non-covalently associates with lymphocyte phosphatase-associated phosphoprotein (LPAP) on T and B lymphocytes. CD45 has been reported to be associated with several other cell surface antigens including CD1, CD2, CD3, and CD4. CD45 has also been reported to bind galectin-1. CD45 isoform expression can change in response to cytokines.