Biotin Anti-Human CD41 Antibody [HIP8] (AGEL0325)

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SKU:
AGEL0325
Product Type:
Antibody
Antibody Type:
Monoclonal Antibody
Reactivity:
Human
Host Species:
Mouse
Isotype:
IgG1
Clone:
HIP8
Conjugation:
Biotin
Applications:
FC
Frequently bought together:

Description

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Biotin Anti-Human CD41 Antibody [HIP8]

The Human CD41 Monoclonal Antibody (Biotin Conjugated, HIP8) is a valuable tool for researchers studying CD41, a surface glycoprotein known for its role in platelet aggregation and clot formation. This monoclonal antibody, derived from hybridoma cell line HIP8, is specifically designed for use in various immunoassays and flow cytometry applications. With a high affinity for human CD41 antigen, this antibody allows for precise detection and analysis of CD41 expression in cell samples, making it an essential component for investigations in hematology, vascular biology, and thrombosis research.CD41, also known as integrin alpha IIb, is a key player in platelet function and coagulation processes essential for hemostasis.

Dysregulation of CD41 expression or function is implicated in various bleeding disorders, thrombotic conditions, and platelet-related diseases. By targeting CD41 with this monoclonal antibody, researchers can gain insights into the mechanisms underlying these conditions and explore potential therapeutic interventions aimed at modulating platelet function and clot formation. This antibody offers researchers a reliable tool for studying the intricate role of CD41 in maintaining normal hemostasis and addressing pathological conditions associated with platelet dysfunction.

Product Title:Biotin Anti-Human CD41 Antibody [HIP8]
SKU:AGEL0325
Size:25µg, 100µg
Clone No:HIP8
Synonyms:Integrin alpha-Iib;ITGA2B;GPalpha Iib;GPIIb;Platelet membrane glycoprotein Iib;CD41;GP2B; ITGAB;
Host Species:Mouse
Reactivity:Human
Application:FCM
Isotype:Mouse IgG1, κ
Isotype Control:Biotin Mouse IgG1, κ Isotype Control[MOPC-21]
Form:Liquid
Conjugation:Biotin
Recommended Use:Each lot of this antibody is quality control tested by flow cytometric analysis. For flow cytometric staining, the suggested use of this reagent is ≤ 1.0 µg per 106 cells in 100 µL volume or 100 µL of whole blood. It is recommended that the reagent be titrated for optimal performance for each application.
Swissprot:P08514
Gene ID:3674
Storage Buffer:Phosphate buffered solution, pH 7.2, containing 0.09% stabilizer and 1% protein protectant.
Stability & Storage:Keep as concentrated solution. Store at 2~8°C and protected from prolonged exposure to light. Do not freeze. Centrifuge before opening to ensure complete recovery of vial contents. This product is guaranteed up to one year from purchase.
Background:CD41 is a 125/25 kD α subunit of the gpIIb/IIIa (CD41/CD61) complex. CD41 is a heterodimer composed of a heavy chain (gpIIbα) and light chain (gpIIbβ) linked by a single disulfide bond. It is a member of the integrin family primarily expressed on platelets and megakaryocytes. CD41 has been reported to be involved with platelet aggregation and platelet attachment to the ECM. CD41/CD61 complex acts as the receptor for fibrinogen, fibronectin, Von Willebrand factor and thrombin.

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