The Human CD40 Monoclonal Antibody (AF488 conjugated) G28-5 (AGEL2099) is a cutting-edge tool designed for precise research applications targeting CD40, a crucial cell surface molecule involved in immune responses. This monoclonal antibody, conjugated with AF488 for enhanced detection capabilities, exhibits high specificity and reactivity with human samples, making it an invaluable asset in various experimental settings.The CD40 protein is integral in activating immune cells, regulating inflammatory responses, and coordinating immune reactions against pathogens, making it a key player in immunology research. By targeting and binding specifically to CD40, this monoclonal antibody facilitates the visualization and analysis of CD40 expression across different cell types, offering valuable insights for studies focused on immunological processes and disease mechanisms.
Researchers in the fields of immunology, cancer biology, and inflammatory disorders will find the Human CD40 Monoclonal Antibody (AF488 conjugated) G28-5 (AGEL2099) to be an indispensable tool for investigating the role of CD40 in health and disease. Its reliability and performance in applications such as immunofluorescence, flow cytometry, and immunohistochemistry make it an ideal choice for gaining a deeper understanding of CD40-mediated pathways and potential therapeutic targets.
Each lot of this antibody is quality control tested by flow cytometric analysis. The amount of the reagent is suggested to be used 5 µL of antibody per test (million cells in 100 µL staining volume or per 100 µL of whole blood). Please check your vial before the experiment. Since applications vary, the appropriate dilutions must be determined for individual use.
Spectrum:
Swissprot:
P25942
Gene ID:
958
Storage Buffer:
Phosphate buffered solution, pH 7.2, containing 0.09% stabilizer and 1% protein protectant.
Stability & Storage:
Keep as concentrated solution. Store at 2~8°C and protected from prolonged exposure to light. Do not freeze. Centrifuge before opening to ensure complete recovery of vial contents. This product is guaranteed up to one year from purchase.
Background:
CD40 is a 48 kD type I glycoprotein also known as BP50. It is a member of the TNFR superfamily primarily expressed on B cells, macrophages, follicular dendritic cells, endothelial cells, fibroblasts, and at low levels on plasma cells. CD40 has been reported to be involved in B cell differentiation, costimulation, isotype class-switching, and protection of B cells from apoptosis. Additionally, CD40 is important for T cell-B cell interactions. The ligand of CD40 is CD154 (CD40 ligand).