The Human CD4 Monoclonal Antibody (PerCP-conjugated) RPA-T4 (AGEL0402) from Assay Genie is a specialized tool for immunological research. This monoclonal antibody is designed specifically for the detection and analysis of the CD4 protein, a key marker of T-helper cells in the immune system. The antibody is conjugated with PerCP, providing a fluorescent signal for flow cytometry and immunofluorescence applications.CD4, a glycoprotein found on the surface of T cells, plays a crucial role in coordinating the immune response by interacting with major histocompatibility complex (MHC) class II molecules on antigen-presenting cells. This interaction is essential for the activation of T cells and the regulation of immune responses.
The Human CD4 Monoclonal Antibody (PerCP-conjugated) RPA-T4 enables researchers to specifically target and study CD4-positive cells in various experimental settings.With its high sensitivity and specificity in detecting CD4, this antibody is a valuable tool for studies focused on immune function, infectious diseases, autoimmune disorders, and HIV/AIDS research. Its reliable performance and precise targeting make it an essential component in the toolkit of scientists and clinicians investigating the complexities of the human immune system.
Each lot of this antibody is quality control tested by flow cytometric analysis. The amount of the reagent is suggested to be used 5 µL of antibody per test (million cells in 100 µL staining volume or per 100 µL of whole blood). Please check your vial before the experiment. Since applications vary, the appropriate dilutions must be determined for individual use.
Spectrum:
Swissprot:
P01730
Gene ID:
920
Storage Buffer:
Phosphate buffered solution, pH 7.2, containing 0.09% stabilizer and 1% protein protectant.
Stability & Storage:
Keep as concentrated solution. Store at 2~8°C and protected from prolonged exposure to light. Do not freeze. Centrifuge before opening to ensure complete recovery of vial contents. This product is guaranteed up to one year from purchase.
Background:
CD4, also known as T4/Leu-3, is a 55 kD single-chain type I transmembrane glycoprotein and member of the immunoglobulin superfamily. It is expressed on most thymocytes, helper T cells, type II NKT cells, and monocytes/macrophages. CD4 is part of the TCR/CD3 complex, binds to β2 domain from the MHC class II molecule, and participates in TCR signal transduction. CD4 is the receptor of IL-16 and is a coreceptor for the human immunodeficiency virus (HIV) and human herpes virus 7 (HHV-7).