Human CD4 (26-396) Recombinant Protein (RPPB0891)

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SKU:
RPPB0891
Product type:
Recombinant Protein
Size:
10ug
Species:
Human
Target:
CD4 (26-396)
Synonyms:
CD4 Molecule
Synonyms:
T-Cell Surface Glycoprotein CD4
Synonyms:
T-CellSurface Antigen T4/Leu-3
Synonyms:
CD4 Antigen (P55)
Source:
Escherichia Coli
Uniprot:
P01730
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Description

Product Name:Human CD4 (26-396) Recombinant Protein
Product Code:RPPB0891
Size:10µg
Species:Human
Target:CD4 (26-396)
Synonyms:CD4 Molecule, T-Cell Surface Glycoprotein CD4, T-CellSurface Antigen T4/Leu-3, CD4 Antigen (P55), CD4 Receptor, CD4 Antigen, CD4mut,T-cell surface glycoprotein CD4.
Source:Escherichia Coli
Physical Appearance:Sterile Filtered colorless solution.
Formulation:CD4 protein solution (0.25mg/ml) containing 20mM Tris Hcl, PH8.0 and 10% glycerol.
Stability:Store at 4°C if entire vial will be used within 2-4 weeks. Store, frozen at -20°C for longer periods of time. For long term storage it is recommended to add a carrier protein (0.1% HSA or BSA).Avoid multiple freeze-thaw cycles.
Purity:Greater than 85% as determined by SDS-PAGE.
Amino Acid Sequence:MGSSHHHHHH SSGLVPRGSH MGSHMKKVVL GKKGDTVELT CTASQKKSIQ FHWKNSNQIK ILGNQGSFLTKGPSKLNDRA DSRRSLWDQG NFPLIIKNLK IEDSDTYICE VEDQKEEVQL LVFGLTANSD THLLQGQSLTLTLESPPGSS PSVQCRSPRG KNIQGGKTLS VSQLELQDSG TWTCTVLQNQ KKVEFKIDIV VLAFQKASSIVYKKEGEQVE FSFPLAFTVE KLTGSGELWW QAERASSSKS WITFDLKNKE VSVKRVTQDP KLQMGKKLPLHLTLPQALPQ YAGSGNLTLA LEAKTGKLHQ EVNLVVMRAT QLQKNLTCEV WGPTSPKLML SLKLENKEAKVSKREKAVWV LNPEAGMWQC LLSDSGQVLL ESNIKVLPTW STPVQP

CD4 is a cell-surface glycoprotein found on the mature helper T cells and immature thymocytes, as well as on monocytes and macrophages. (Some cytotoxic T cells have CD4 protein as well.) Normally, about 65% of T cells in the blood are CD4+ (have CD4 protein protruding from their membrane). A mature T cell with either have CD4 or CD8, but not both. During one stage of development T cells develop CD4 and CD8 receptors, but they eventually are differentiated in the thymus and become more specialized.

CD4 Human Recombinant produced in E.Coli is a single, non-glycosylatedpolypeptide chain containing 396 amino acids (26-396 a.a) and having amolecular mass of 44kDa.CD4 is fused to a 25 amino acid His-tag at N-terminus& purified by proprietary chromatographic techniques.

UniProt Protein Function:CD4: Accessory protein for MHC class-II antigen/T-cell receptor interaction. May regulate T-cell activation. Induces the aggregation of lipid rafts. Associates with LCK. Binds to HIV-1 gp120 and to P4HB/PDI and upon HIV-1 binding to the cell membrane, is part of P4HB/PDI- CD4-CXCR4-gp120 complex. Interacts with HIV-1 Envelope polyprotein gp160 and protein Vpu. Interacts with Human Herpes virus 7 capsid proteins. Interacts with PTK2/FAK1; this interaction requires the presence of HIV-1 gp120.
UniProt Protein Details:

Protein type:Membrane protein, integral; Cell surface

Chromosomal Location of Human Ortholog: 12p13.31

Cellular Component: T cell receptor complex; endoplasmic reticulum membrane; endoplasmic reticulum lumen; early endosome; plasma membrane; integral to membrane; external side of plasma membrane; lipid raft

Molecular Function:protein binding; enzyme binding; transmembrane receptor activity; protein homodimerization activity; zinc ion binding; extracellular matrix structural constituent; coreceptor activity; receptor activity; glycoprotein binding; protein kinase binding; MHC class II protein binding

Biological Process: maintenance of cellular protein localization; viral reproduction; positive regulation of interleukin-2 biosynthetic process; cytokine production; T cell selection; positive regulation of calcium-mediated signaling; defense response to Gram-negative bacterium; signal transduction; induction by virus of cell-cell fusion in host; T cell receptor signaling pathway; enzyme linked receptor protein signaling pathway; regulation of defense response to virus by virus; positive regulation of peptidyl-tyrosine phosphorylation; cell surface receptor linked signal transduction; positive regulation of protein kinase activity; T cell costimulation; protein palmitoleylation; innate immune response; entry into host cell; immune response; transmembrane receptor protein tyrosine kinase signaling pathway; T cell differentiation; regulation of T cell activation

Disease: Okt4 Epitope Deficiency

NCBI Summary:This gene encodes a membrane glycoprotein of T lymphocytes that interacts with major histocompatibility complex class II antigenes and is also a receptor for the human immunodeficiency virus. This gene is expressed not only in T lymphocytes, but also in B cells, macrophages, and granulocytes. It is also expressed in specific regions of the brain. The protein functions to initiate or augment the early phase of T-cell activation, and may function as an important mediator of indirect neuronal damage in infectious and immune-mediated diseases of the central nervous system. Multiple alternatively spliced transcript variants encoding different isoforms have been identified in this gene. [provided by RefSeq, Aug 2010]
UniProt Code:P01730
NCBI GenInfo Identifier:116013
NCBI Gene ID:920
NCBI Accession:P01730.1
UniProt Secondary Accession:P01730,Q4ZGK2, Q5U066, Q9UDE5, B2R737, D3DUS5,
UniProt Related Accession:P01730
Molecular Weight:458
NCBI Full Name:T-cell surface glycoprotein CD4
NCBI Synonym Full Names:CD4 molecule
NCBI Official Symbol:CD4  
NCBI Official Synonym Symbols:CD4mut  
NCBI Protein Information:T-cell surface glycoprotein CD4; CD4 receptor; CD4 antigen (p55); T-cell surface antigen T4/Leu-3
UniProt Protein Name:T-cell surface glycoprotein CD4
UniProt Synonym Protein Names:T-cell surface antigen T4/Leu-3; CD_antigen: CD4
Protein Family:CD40 ligand
UniProt Gene Name:CD4  
UniProt Entry Name:CD4_HUMAN
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