Purified Anti-Human CD3 Antibody [OKT-3] (AGEL0055)

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SKU:
AGEL0055
Product Type:
Antibody
Antibody Type:
Monoclonal Antibody
Reactivity:
Human
Host Species:
Mouse
Isotype:
IgG2a
Clone:
OKT3
Conjugation:
Unconjugated
Applications:
FC
IHC
Frequently bought together:

Description

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Purified Anti-Human CD3 Antibody [OKT-3]

The Human CD3 Monoclonal Antibody (OKT3) is designed for specialized research involving CD3, a pivotal cell surface molecule critical for T-cell activation and immune response regulation. This monoclonal antibody, developed in mice, displays high reactivity with human samples and is validated for use in flow cytometry and immunohistochemistry applications. It binds specifically to the CD3 protein, enabling precise detection and analysis across various cell types, making it an ideal choice for studies in immunology and cancer research.CD3 is an essential component of the T-cell receptor (TCR) complex, playing a crucial role in initiating and modulating T-cell responses. Its significance in immune regulation makes it a valuable target for research into diseases such as cancer, autoimmune disorders, and chronic inflammatory conditions.

The Human CD3 Monoclonal Antibody (OKT3) is indispensable for researchers aiming to understand T-cell biology and develop therapies that enhance or suppress immune function.By providing accurate and reliable detection of CD3, this antibody supports comprehensive studies of immune response pathways, contributing to the advancement of immunotherapy and the development of innovative treatments for immune-related diseases. Understanding the activity of CD3 is crucial for creating targeted therapies that harness or modulate immune function, making this antibody a valuable asset for advancing research in immunology and cancer.

Product Title:Purified Anti-Human CD3 Antibody [OKT-3]
SKU:AGEL0055
Size:25µg, 100µg
Clone No:OKT-3
Synonyms:T-cell surface glycoprotein CD3 epsilon chain;CD3E;T-cell surface antigen T3/Leu-4 epsilon chain;CD3e;CD3E;T3E;
Host Species:Mouse
Reactivity:Human
Application:FCM
Isotype:Mouse IgG2a, κ
Isotype Control:Purified Mouse IgG2a, κ Isotype Control[C1.18.4]
Form:Liquid
Conjugation:Unconjugated
Recommended Use:Each lot of this antibody is quality control tested by flow cytometric analysis. For flow cytometric staining, the suggested use of this reagent is ≤ 0.5 µg per 106 cells in 100 µL volume or 100 µL of whole blood. It is recommended that the reagent be titrated for optimal performance for each application.
Swissprot:P07766
Gene ID:916
Storage Buffer:Phosphate buffered solution, pH 7.2, containing 0.09% stabilizer.
Stability & Storage:Keep as concentrated solution. Store at 2~8°C and protected from prolonged exposure to light. Do not freeze. Centrifuge before opening to ensure complete recovery of vial contents. This product is guaranteed up to one year from purchase.
Background:CD3ε is a 20 kD chain of the CD3/T cell receptor (TCR) complex, which is composed of two CD3ε, one CD3γ, one CD3δ, one CD3ζ (CD247), and a T cell receptor (α/β or γ/δ) heterodimer. It is found on all mature T lymphocytes, NK T cells, and some thymocytes. CD3, also known as T3, is a member of the immunoglobulin superfamily that plays a role in antigen recognition, signal transduction, and T cell activation.

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