Biotin Anti-Human CD3 Antibody [OKT-3] (AGEL0056)

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SKU:
AGEL0056
Product Type:
Antibody
Antibody Type:
Monoclonal Antibody
Reactivity:
Human
Host Species:
Mouse
Isotype:
IgG2a
Clone:
OKT3
Conjugation:
Biotin
Applications:
FC
Frequently bought together:

Description

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Biotin Anti-Human CD3 Antibody [OKT-3]

The Biotin-Conjugated Human CD3 Monoclonal Antibody (OKT3) is designed for advanced research targeting CD3, a crucial cell surface molecule essential for T-cell activation and immune response regulation. This monoclonal antibody, raised in mice, is highly reactive with human samples and validated for use in flow cytometry applications. The biotin conjugation enhances detection and quantification through various biotin-avidin/streptavidin-based assay systems, ensuring precise and reliable results.CD3 is a vital component of the T-cell receptor (TCR) complex, playing a significant role in initiating and modulating T-cell responses. Its importance in immune regulation makes CD3 a valuable target for research into diseases such as cancer, autoimmune disorders, and chronic inflammatory conditions.

The Biotin-Conjugated Human CD3 Monoclonal Antibody (OKT3) is an indispensable tool for researchers aiming to explore T-cell biology and develop therapies that either enhance or suppress immune function.By enabling accurate and sensitive detection of CD3, this antibody supports comprehensive studies of immune response pathways, contributing to the development of novel therapeutic strategies for immune-related diseases. Understanding the activity of CD3 is crucial for creating targeted therapies that harness or modulate immune function, making this antibody a critical asset for advancing research in immunology and cancer.

Product Title:Biotin Anti-Human CD3 Antibody [OKT-3]
SKU:AGEL0056
Size:25µg, 100µg
Clone No:OKT-3
Synonyms:T-cell surface glycoprotein CD3 epsilon chain;CD3E;T-cell surface antigen T3/Leu-4 epsilon chain;CD3e;CD3E;T3E;
Host Species:Mouse
Reactivity:Human
Application:FCM
Isotype:Mouse IgG2a, κ
Isotype Control:Biotin Mouse IgG2a, κ Isotype Control[C1.18.4]
Form:Liquid
Conjugation:Biotin
Recommended Use:Each lot of this antibody is quality control tested by flow cytometric analysis. For flow cytometric staining, the suggested use of this reagent is ≤ 1.0 µg per 106 cells in 100 µL volume or 100 µL of whole blood. It is recommended that the reagent be titrated for optimal performance for each application.
Swissprot:P07766
Gene ID:916
Storage Buffer:Phosphate buffered solution, pH 7.2, containing 0.09% stabilizer and 1% protein protectant.
Stability & Storage:Keep as concentrated solution. Store at 2~8°C and protected from prolonged exposure to light. Do not freeze. Centrifuge before opening to ensure complete recovery of vial contents. This product is guaranteed up to one year from purchase.
Background:CD3ε is a 20 kD chain of the CD3/T cell receptor (TCR) complex, which is composed of two CD3ε, one CD3γ, one CD3δ, one CD3ζ (CD247), and a T cell receptor (α/β or γ/δ) heterodimer. It is found on all mature T lymphocytes, NK T cells, and some thymocytes. CD3, also known as T3, is a member of the immunoglobulin superfamily that plays a role in antigen recognition, signal transduction, and T cell activation.

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