The Human CD29 Monoclonal Antibody (AF647 conjugated; TS2/16) is a valuable tool for researchers studying CD29, a cell surface protein known for its role in cell adhesion and signaling processes. This monoclonal antibody, conjugated with AF647 for fluorescence-based applications, is highly specific to human CD29 and is suitable for various experimental techniques.CD29, also referred to as integrin β1, is a key player in cell-extracellular matrix interactions, cell migration, and tissue organization. Its involvement in cellular processes across different tissues and its implications in various diseases make it a crucial target for investigation in the fields of cell biology, cancer research, and regenerative medicine.
By utilizing the Human CD29 Monoclonal Antibody (AF647 conjugated; TS2/16), researchers can accurately detect and analyze the expression of CD29 in different cell types and tissues. This antibody enables the visualization and quantification of CD29 levels, aiding in the understanding of its functions and regulatory mechanisms. With its reliability and specificity, this antibody is a valuable asset for studies focused on cell adhesion, migration, and tissue remodeling processes associated with CD29.
Each lot of this antibody is quality control tested by flow cytometric analysis. The amount of the reagent is suggested to be used 5 µL of antibody per test (million cells in 100 µL staining volume or per 100 µL of whole blood). Please check your vial before the experiment. Since applications vary, the appropriate dilutions must be determined for individual use.
Spectrum:
Swissprot:
P05556
Gene ID:
3688
Storage Buffer:
Phosphate buffered solution, pH 7.2, containing 0.09% stabilizer and 1% protein protectant.
Stability & Storage:
Keep as concentrated solution. Store at 2~8°C and protected from prolonged exposure to light. Do not freeze. Centrifuge before opening to ensure complete recovery of vial contents. This product is guaranteed up to one year from purchase.
Background:
CD29 is a 130 kD single chain type I glycoprotein also known as integrin β1, VLA-β chain, or gpIIa. It is broadly expressed on a majority of hematopoietic and non-hematopoietic cells, including leukocytes (although at low level on granulocytes), platelets, fibroblasts, endothelial cells, epithelial cells, and mast cells. CD29 is a member of the integrin family. It is non-covalently associated with integrin α1-α6 chains to form VLA-1 to VLA-6 molecules, respectively. Integrins, which include CD29, bind to several cell surface (e.g. VCAM-1, MadCAM-1) and extracellular matrix molecules. CD29 acts as a fibronectin receptor and is involved in a variety of cell-cell and cell-matrix interactions.