APC Anti-Human CD28 Antibody [CD28.2] (AGEL2022)

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SKU:
AGEL2022
Product Type:
Antibody
Antibody Type:
Monoclonal Antibody
Reactivity:
Human
Applications:
FC
Frequently bought together:

Description

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APC Anti-Human CD28 Antibody [CD28.2]

The Human CD28 Monoclonal Antibody (APC-conjugated) CD28-2 (AGEL2022) is an essential tool for researchers studying the CD28 protein, a key co-stimulatory molecule involved in T cell activation and immune responses. This monoclonal antibody, conjugated to APC for flow cytometry applications, exhibits high specificity and reactivity with human samples, making it an ideal choice for experiments in immunology and cellular biology.CD28 plays a pivotal role in T cell co-stimulation, providing the second signal necessary for T cell activation and proliferation upon interaction with its ligands. By targeting CD28 with this monoclonal antibody, researchers can accurately detect and analyze CD28 expression on T cells, thereby gaining insights into the T cell-mediated immune responses and potential therapeutic interventions.

With its validated performance in flow cytometry experiments, the Human CD28 Monoclonal Antibody (APC-conjugated) CD28-2 (AGEL2022) offers a reliable tool for investigating T cell activation, immune regulation, and therapeutic targeting of the CD28 pathway. Explore the dynamic world of T cell biology and immune modulation with this high-quality antibody, paving the way for innovative research in immunotherapy, infectious diseases, and autoimmune disorders.

Product Title:APC Anti-Human CD28 Antibody [CD28.2]
SKU:AGEL2022
Size:20 Tests, 100 Tests, 200 Tests
Clone No:CD28.2
Synonyms:PAS2;MNS;HGpMiX;GYPA;GPSAT;
Host Species:Mouse
Reactivity:Human
Application:FCM
Isotype:Mouse IgG1, κ
Isotype Control:APC Mouse IgG1, κ Isotype Control[MOPC-21]
Form:Liquid
Conjugation:APC
Recommended Use:Each lot of this antibody is quality control tested by flow cytometric analysis. The amount of the reagent is suggested to be used 5 µL of antibody per test (million cells in 100 µL staining volume or per 100 µL of whole blood). Please check your vial before the experiment. Since applications vary, the appropriate dilutions must be determined for individual use.
Spectrum:Spectrum Image
Swissprot:P10747
Gene ID:940
Storage Buffer:Phosphate buffered solution, pH 7.2, containing 0.09% stabilizer and 1% protein protectant.
Stability & Storage:Keep as concentrated solution. Store at 2~8°C and protected from prolonged exposure to light. Do not freeze. Centrifuge before opening to ensure complete recovery of vial contents. This product is guaranteed up to one year from purchase.
Background:CD28 is a 44 kD disulfide-linked homodimeric type I glycoprotein. It is a member of the immunoglobulin superfamily and is also known as T44 or Tp44. CD28 is expressed on most T lineage cells, NK cell subsets, and plasma cells. CD28 binds both CD80 and CD86 using a highly conserved motif MYPPY in the CDR3-like loop. CD28 is considered a major co-stimulatory molecule, inducing T lymphocyte activation and IL-2 synthesis, and preventing cell death. In vitro studies indicate that ligation of CD28 on T cells by CD80 and CD86 on antigen presenting cells provides a costimulatory signal required for T cell activation and proliferation.

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