Human CD27 Recombinant Protein (RPPB3050)
- SKU:
- RPPB3050
- Product type:
- Recombinant Protein
- Size:
- 5ug
- Species:
- Human
- Target:
- CD27
- Synonyms:
- Tumor Necrosis Factor Receptor Superfamily Member 7
- T-Cell Activation Antigen CD27
- CD27 Molecule
- CD27 Antigen
- Source:
- Sf9 Insect cells
- Uniprot:
- P26842
Description
| Product Name: | Human CD27 Recombinant Protein |
| Product Code: | RPPB3050 |
| Size: | 5µg |
| Species: | Human |
| Target: | CD27 |
| Synonyms: | Tumor Necrosis Factor Receptor Superfamily Member 7, T-Cell Activation Antigen CD27, CD27 Molecule, CD27 Antigen, T Cell Activation Antigen S152, CD27L Receptor, TNFRSF7, S152, Tp55, T14. |
| Source: | Sf9 Insect cells |
| Physical Appearance: | Sterile Filtered colorless solution. |
| Formulation: | CD27 protein solution (0.5mg/ml) contains Phosphate Buffered Saline (pH7.4) and 10% glycerol. |
| Stability: | Store at 4°C if entire vial will be used within 2-4 weeks. Store, frozen at -20°C for longer periods of time. For long term storage it is recommended to add a carrier protein (0.1% HSA or BSA). Avoid multiple freeze-thaw cycles. |
| Purity: | Greater than 85.0% as determined by SDS-PAGE. |
| Amino Acid Sequence: | ADPTPAPKSC PERHYWAQGK LCCQMCEPGT FLVKDCDQHR KAAQCDPCIP GVSFSPDHHT RPHCESCRHC NSGLLVRNCT ITANAECACR NGWQCRDKEC TECDPLPNPS LTARSSQALS PHPQPTHLPY VSEMLEARTA GHMQTLADFR QLPARTLSTH WPPQRSLCSS DFIRLEPKSC DKTHTCPPCP APELLGGPSV FLFPPKPKDT LMISRTPEVT CVVVDVSHED PEVKFNWYVD GVEVHNAKTK PREEQYNSTY RVVSVLTVLH QDWLNGKEYK CKVSNKALPA PIEKTISKAK GQPREPQVYT LPPSRDELTK NQVSLTCLVK GFYPSDIAVE WESNGQPENN YKTTPPVLDS DGSFFLYSKL TVDKSRWQQG NVFSCSVMHE ALHNHYTQKS LSLSPGKHHH HHH |
CD27 belongs to the TNF-receptor superfamily. CD27 is necessary for initiation and long-term maintenance of T cell immunity. CD27 binds to ligand CD70, and has a crucial role in regulating B-cell activation and immunoglobulin synthesis. The CD27 receptor transduces signals which result in the activation of NF-kappaB and MAPK8/JNK. Adaptor proteins TRAF2 and TRAF5 mediate the signaling process of CD27. CD27-binding protein (SIVA), which is a proapoptotic protein, can bind to the CD27 receptor and is believed to have a significant role in the apoptosis induced by CD27.
CD27 Human Recombinant produced in Sf9 Baculovirus cells is a single, glycosylated polypeptide chain containing 413 amino acids (21-191a.a.) and having a molecular mass of 46.4kDa (Molecular size on SDS-PAGE will appear at approximately 28-57kDa).CD27 is fused with a 239 amino acids hIgG-His tag at C-Terminus and purified by proprietary chromatographic techniques.
| UniProt Protein Function: | CD27: Receptor for CD70/CD27L. May play a role in survival of activated T-cells. May play a role in apoptosis through association with SIVA1. |
| UniProt Protein Details: | Protein type:Membrane protein, integral; Apoptosis; Receptor, cytokine Chromosomal Location of Human Ortholog: 12p13 Cellular Component: integral to plasma membrane; neuron projection; nucleus; plasma membrane Molecular Function:caspase inhibitor activity; protein binding; tumor necrosis factor receptor activity Biological Process: brain development; immune response; induction of apoptosis via death domain receptors; inflammatory response; negative regulation of apoptosis; positive regulation of JNK cascade; positive regulation of MAPKKK cascade; regulation of cell proliferation; response to lipopolysaccharide; tumor necrosis factor-mediated signaling pathway Disease: Lymphoproliferative Syndrome 2 |
| NCBI Summary: | The protein encoded by this gene is a member of the TNF-receptor superfamily. This receptor is required for generation and long-term maintenance of T cell immunity. It binds to ligand CD70, and plays a key role in regulating B-cell activation and immunoglobulin synthesis. This receptor transduces signals that lead to the activation of NF-kappaB and MAPK8/JNK. Adaptor proteins TRAF2 and TRAF5 have been shown to mediate the signaling process of this receptor. CD27-binding protein (SIVA), a proapoptotic protein, can bind to this receptor and is thought to play an important role in the apoptosis induced by this receptor. [provided by RefSeq, Jul 2008] |
| UniProt Code: | P26842 |
| NCBI GenInfo Identifier: | 269849546 |
| NCBI Gene ID: | 939 |
| NCBI Accession: | P26842.2 |
| UniProt Secondary Accession: | P26842,B2RDZ0, |
| UniProt Related Accession: | P26842 |
| Molecular Weight: | 29,137 Da |
| NCBI Full Name: | CD27 antigen |
| NCBI Synonym Full Names: | CD27 molecule |
| NCBI Official Symbol: | CD27 |
| NCBI Official Synonym Symbols: | T14; S152; Tp55; TNFRSF7; S152. LPFS2 |
| NCBI Protein Information: | CD27 antigen |
| UniProt Protein Name: | CD27 antigen |
| UniProt Synonym Protein Names: | CD27L receptor; T-cell activation antigen CD27; T14; Tumor necrosis factor receptor superfamily member 7; CD_antigen: CD27 |
| Protein Family: | CD27 antigen |
| UniProt Gene Name: | CD27 |
| UniProt Entry Name: | CD27_HUMAN |
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