The Human CD27 Monoclonal Antibody (APC conjugated) - O323 (AG-EL1708) offered by AssayGenie is a cutting-edge tool for researchers studying CD27, a crucial cell surface marker involved in immune response modulation. This monoclonal antibody, conjugated with allophycocyanin (APC), is specifically designed for use in flow cytometry applications, allowing for efficient detection and analysis of CD27 expression in human samples.CD27, also known as Tumor Necrosis Factor Receptor Superfamily Member 7 (TNFRSF7), is renowned for its role in regulating T-cell activation and differentiation, making it a key player in adaptive immunity. The CD27 Monoclonal Antibody targets this protein, enabling precise identification and characterization of CD27-expressing cells in various research settings.
By utilizing this APC-conjugated monoclonal antibody, researchers can delve deeper into the functions of CD27 in immune responses, infectious diseases, autoimmune disorders, and cancer immunotherapy. The high specificity and sensitivity of this antibody make it an essential tool for immunologists, oncologists, and other scientists aiming to unravel the complexities of immune system regulation.Enhance your research capabilities and accelerate your discoveries with the Human CD27 Monoclonal Antibody (APC conjugated) - O323 (AG-EL1708) from AssayGenie.
Each lot of this antibody is quality control tested by flow cytometric analysis. The amount of the reagent is suggested to be used 5 µL of antibody per test (million cells in 100 µL staining volume or per 100 µL of whole blood). Please check your vial before the experiment. Since applications vary, the appropriate dilutions must be determined for individual use.
Spectrum:
Swissprot:
P26842
Gene ID:
939
Storage Buffer:
Phosphate buffered solution, pH 7.2, containing 0.09% stabilizer and 1% protein protectant.
Stability & Storage:
Keep as concentrated solution. Store at 2~8°C and protected from prolonged exposure to light. Do not freeze. Centrifuge before opening to ensure complete recovery of vial contents. This product is guaranteed up to one year from purchase.
Background:
CD27 is a 50-55 kD type I membrane protein also known as S152 and T14. It is a lymphocyte-specific member of the TNF-receptor superfamily. CD27 is expressed on medullary thymocytes, virtually all mature T cells, some B cells, and NK cells. CD27 binds to CD70 and plays an important role in costimulation of T cell activation, and regulation of B cell differentiation and proliferation. The cytoplasmic domains of CD27 have also been shown to interact with TRAF2 and TRAF5 to elicit NF-κB and SAPK/JNK activation.