Human CD2 Recombinant Protein (RPPB3015)

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SKU:
RPPB3015
Product type:
Recombinant Protein
Size:
5ug
Species:
Human
Target:
CD2
Synonyms:
T-cell surface antigen CD2
Synonyms:
T-cell surface antigen T11/Leu-5
Synonyms:
LFA-2
Synonyms:
LFA-3 receptor
Source:
Escherichia Coli
Uniprot:
P06729
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Description

Product Name:Human CD2 Recombinant Protein
Product Code:RPPB3015
Size:5µg
Species:Human
Target:CD2
Synonyms:T-cell surface antigen CD2, T-cell surface antigen T11/Leu-5, LFA-2, LFA-3 receptor, Erythrocyte receptor, Rosette receptor, CD2 antigen, CD2, T11, SRBC.
Source:Escherichia Coli
Physical Appearance:Sterile Filtered clear solution.
Formulation:CD2 at 100µg/ml in 50mM Tris-HCl pH7.5 and 10Mm L-glutathione (reduced).
Stability:Store vial at -20°C to -80°C. When stored at the recommended temperature, this protein is stable for 12 months.Please prevent freeze-thaw cycles.

CD2 which is also known as E-rosette receptor, T11 and lymphocytefunction antigen-2 (LFA-2) is expressed on T cells, thymocytes, and subset of natural killer cells. Human CD2 functions as the receptor for sheep erythrocytes, human CD58 (LFA-3), and CD15s (Sialyl Lewis X). p56lck, p59fyn, CD3eta and CD3epsilon are tyrosine-phosphorylated after CD2 stimulation. CD2 plays a role in T cell activation, T- or NK-cell-mediated cytolysis, apoptosis in activated peripheral T cells, and regulation of T cell anergy.

CD2 Human Recombinant (aa 25-209) expressed in E.coli, shows a 46 kDa band on SDS-PAGE.The CD2 is purified by proprietary chromatographic techniques.

UniProt Protein Function:CD2: CD2 interacts with lymphocyte function-associated antigen (LFA-3) and CD48/BCM1 to mediate adhesion between T-cells and other cell types. CD2 is implicated in the triggering of T- cells, the cytoplasmic domain is implicated in the signaling function.
UniProt Protein Details:

Protein type:Cell surface; Membrane protein, integral; Apoptosis

Chromosomal Location of Human Ortholog: 1p13.1

Cellular Component: anchored to plasma membrane; cell surface; external side of plasma membrane; extracellular region; integral to plasma membrane; intercellular junction; internal side of plasma membrane; plasma membrane

Molecular Function:protein binding; protein homodimerization activity; receptor activity; receptor binding

Biological Process: apoptosis; cell surface receptor linked signal transduction; cell-cell adhesion; heterotypic cell-cell adhesion; leukocyte migration; lipid raft polarization; natural killer cell activation; positive regulation of myeloid dendritic cell activation; positive regulation of tumor necrosis factor production; regulation of T cell differentiation; T cell activation

NCBI Summary:CD2 is a surface antigen of the human T-lymphocyte lineage that is expressed on all peripheral blood T cells (summarized by Sewell et al., 1986 [PubMed 3490670]). It is one of the earliest T-cell markers, being present on more than 95% of thymocytes; it is also found on some natural killer cells but not on B lymphocytes. Monoclonal antibodies directed against CD2 inhibit the formation of rosettes with sheep erythrocytes, indicating that CD2 is the erythrocyte receptor or is closely associated with it.[supplied by OMIM, Jul 2010]
UniProt Code:P06729
NCBI GenInfo Identifier:160370002
NCBI Gene ID:914
NCBI Accession:P06729.2
UniProt Secondary Accession:P06729,Q96TE5,
UniProt Related Accession:P06729
Molecular Weight:39,448 Da
NCBI Full Name:T-cell surface antigen CD2
NCBI Synonym Full Names:CD2 molecule
NCBI Official Symbol:CD2  
NCBI Official Synonym Symbols:T11; SRBC; LFA-2  
NCBI Protein Information:T-cell surface antigen CD2
UniProt Protein Name:T-cell surface antigen CD2
UniProt Synonym Protein Names:Erythrocyte receptor; LFA-2; LFA-3 receptor; Rosette receptor; T-cell surface antigen T11/Leu-5; CD_antigen: CD2
Protein Family:CD2
UniProt Gene Name:CD2  
UniProt Entry Name:CD2_HUMAN
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