The Human CD1a Monoclonal Antibody (APC-conjugated OKT-6, AGEL1589) is a specialized tool for researchers studying CD1a, a cell surface glycoprotein involved in antigen presentation and immune responses. This antibody, based on the OKT-6 clone, is specifically designed for flow cytometry applications and provides high specificity and sensitivity when detecting human CD1a. CD1a is a marker for a subset of dendritic cells and thymocytes, playing a vital role in presenting lipid antigens to T cells and initiating immune responses. By targeting CD1a with this monoclonal antibody conjugated to APC, researchers can effectively identify and analyze CD1a-expressing cells in various biological samples.
This makes it an invaluable tool for immunologists, oncologists, and researchers studying autoimmune diseases and infectious conditions.With its strong reactivity towards human CD1a and validated performance in flow cytometry, the Human CD1a Monoclonal Antibody (APC-conjugated OKT-6, AGEL1589) opens up new possibilities for investigating the immune system's intricacies and developing targeted therapies for immune-related disorders.
Each lot of this antibody is quality control tested by flow cytometric analysis. The amount of the reagent is suggested to be used 5 µL of antibody per test (million cells in 100 µL staining volume or per 100 µL of whole blood). Please check your vial before the experiment. Since applications vary, the appropriate dilutions must be determined for individual use.
Spectrum:
Swissprot:
P06126
Gene ID:
909
Storage Buffer:
Phosphate buffered solution, pH 7.2, containing 0.09% stabilizer and 1% protein protectant.
Stability & Storage:
Keep as concentrated solution. Store at 2~8°C and protected from prolonged exposure to light. Do not freeze. Centrifuge before opening to ensure complete recovery of vial contents. This product is guaranteed up to one year from purchase.
Background:
CD1a is a 49 kD member of the immunoglobulin superfamily also known as T6 and R4. It is a type I membrane glycoprotein with structural similarities to MHC class I and is non-covalently associated with β2-microglobulin. CD1a plays a role in non-peptide glycolipid antigen presentation to CD1-restricted T cells. It is expressed on cortical double positive and single positive thymocytes, Langerhans cells, and dendritic cells. In addition to antigen presentation, CD1a has been implicated in thymic T cell development.