PerCP/Cyanine5.5 Anti-Human CD197/CCR7 Antibody [G043H7] (AGEL1808)

(No reviews yet) Write a Review
SKU:
AGEL1808
Product Type:
Antibody
Antibody Type:
Monoclonal Antibody
Applications:
FC
Reactivity:
Human
Host Species:
Mouse
Isotype:
IgG2a,k
Clone:
G043H7
Conjugation:
PerCP/Cy5.5
Frequently bought together:

Description

system_update_altDatasheetsystem_update_altMSDS

PerCP/Cyanine5.5 Anti-Human CD197/CCR7 Antibody [G043H7]

The Human CD197 (CCR7) Monoclonal Antibody, PerCP-Cyanine5.5 Conjugated (G043H7-AGEL1808) is a cutting-edge tool for researchers studying immune cell migration and homing. This antibody specifically targets CD197, also known as CCR7, a key chemokine receptor involved in the directional movement of T cells and dendritic cells towards secondary lymphoid organs.Developed using advanced technology, this monoclonal antibody offers high specificity and sensitivity when detecting CD197 in human samples. The PerCP-Cyanine5.5 conjugation provides enhanced signal strength and excellent fluorescence properties, facilitating accurate analysis in flow cytometry and immunofluorescence applications.CCR7 is crucial for the immune system's ability to mount effective responses to pathogens and antigens by guiding immune cells to the appropriate locations for immune surveillance and activation.

By targeting CCR7 with this antibody, researchers can gain valuable insights into immune cell trafficking mechanisms and the role of CCR7 in immune responses, inflammation, and lymphoid organ development.Whether investigating immune cell behavior in infectious diseases, cancer, or autoimmune disorders, the Human CD197 Monoclonal Antibody offers a reliable tool to advance understanding in immunology research and drug development. Harness the power of precise targeting and detection with this innovative antibody for in-depth exploration of immune cell migration pathways and therapeutic opportunities.

Product Title:PerCP/Cyanine5.5 Anti-Human CD197/CCR7 Antibody [G043H7]
SKU:AGEL1808
Size:20 Tests, 100 Tests, 200 Tests
Clone No:G043H7
Synonyms:CMKBR7; EBI1; EVI1;CCR-7;CDw197;
Host Species:Mouse
Reactivity:Human
Application:FCM
Isotype:Mouse IgG2a, κ
Isotype Control:PerCP/Cyanine5.5 Mouse IgG2a, κ Isotype Control[C1.18.4]
Form:Liquid
Conjugation:PerCP/Cyanine 5.5
Recommended Use:Each lot of this antibody is quality control tested by flow cytometric analysis. The amount of the reagent is suggested to be used 5 µL of antibody per test (million cells in 100 µL staining volume or per 100 µL of whole blood). Please check your vial before the experiment. Since applications vary, the appropriate dilutions must be determined for individual use.
Spectrum:Spectrum Image
Swissprot:P32248
Gene ID:1236
Storage Buffer:Phosphate buffered solution, pH 7.2, containing 0.09% stabilizer and 1% protein protectant.
Stability & Storage:Keep as concentrated solution. Store at 2~8°C and protected from prolonged exposure to light. Do not freeze. Centrifuge before opening to ensure complete recovery of vial contents. This product is guaranteed up to one year from purchase.
Background:CCR7, also known as CD197, is a chemokine receptor that binds CCL19 and CCL21. CCR7 and its ligands link innate and adaptive immunity by affecting interactions between T cells and dendritic cells and their downstream effect. Naïve T cells enter the lymph node through high endothelial venules, which express CCL21. Dendritic cells and macrophages enter the lymph node through afferent lymphatics. The encounter of T cells and dendritic cells in the T cell zone is CCR7-dependent. In addition, during immunological surveillance, B cells recirculate between B-cell-rich compartments (follicles or B cell zones) in secondary lymphoid organs, surveying for antigen. After antigen binding, B cells move to the boundary of B and T zones to interact with T-helper cells; this B cell migration is directed by CCR7 and its ligands. CCR7-positive cancer cell expression has been associated with lymph node metastasis.

0 Reviews

View AllClose

Related Products