PE Anti-Human CD197/CCR7 Antibody [G043H7] (AGEL1803)

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SKU:
AGEL1803
Product Type:
Antibody
Antibody Type:
Monoclonal Antibody
Applications:
FC
Reactivity:
Human
Host Species:
Mouse
Isotype:
IgG2a,k
Clone:
G043H7
Conjugation:
PE
Frequently bought together:

Description

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PE Anti-Human CD197/CCR7 Antibody [G043H7]

The CD197 (CCR7) Monoclonal Antibody (PE Conjugated) is a powerful tool designed for research applications involving the human CD197 protein, also known as CCR7. This monoclonal antibody, labeled with phycoerythrin (PE), is raised in mice and demonstrates high specificity and sensitivity for human samples.CCR7 is a chemokine receptor that plays a crucial role in regulating the migration and homing of immune cells, particularly lymphocytes, to secondary lymphoid organs. Its involvement in immune cell trafficking and immune responses makes it a key target for studies in immunology and related fields. By binding specifically to the CD197 protein, this antibody enables the detection and analysis of CCR7 expression in various cell types, providing valuable insights into immune cell behavior and function.

Researchers studying immune cell migration, lymphocyte activation, and immune response modulation will find this PE-conjugated monoclonal antibody to be an essential tool for their experiments. With its reliable performance in flow cytometry and other related assays, this antibody facilitates the investigation of CCR7-mediated processes, offering new opportunities for advancing our understanding of immune system dynamics and its implications in health and disease.

Product Title:PE Anti-Human CD197/CCR7 Antibody [G043H7]
SKU:AGEL1803
Size:20 Tests, 100 Tests, 200 Tests
Clone No:G043H7
Synonyms:CMKBR7; EBI1; EVI1;CCR-7;CDw197;
Host Species:Mouse
Reactivity:Human
Application:FCM
Isotype:Mouse IgG2a, κ
Isotype Control:PE Mouse IgG2a, κ Isotype Control[C1.18.4]
Form:Liquid
Conjugation:PE
Recommended Use:Each lot of this antibody is quality control tested by flow cytometric analysis. The amount of the reagent is suggested to be used 5 µL of antibody per test (million cells in 100 µL staining volume or per 100 µL of whole blood). Please check your vial before the experiment. Since applications vary, the appropriate dilutions must be determined for individual use.
Spectrum:Spectrum Image
Swissprot:P32248
Gene ID:1236
Storage Buffer:Phosphate buffered solution, pH 7.2, containing 0.09% stabilizer and 1% protein protectant.
Stability & Storage:Keep as concentrated solution. Store at 2~8°C and protected from prolonged exposure to light. Do not freeze. Centrifuge before opening to ensure complete recovery of vial contents. This product is guaranteed up to one year from purchase.
Background:CCR7, also known as CD197, is a chemokine receptor that binds CCL19 and CCL21. CCR7 and its ligands link innate and adaptive immunity by affecting interactions between T cells and dendritic cells and their downstream effect. Naïve T cells enter the lymph node through high endothelial venules, which express CCL21. Dendritic cells and macrophages enter the lymph node through afferent lymphatics. The encounter of T cells and dendritic cells in the T cell zone is CCR7-dependent. In addition, during immunological surveillance, B cells recirculate between B-cell-rich compartments (follicles or B cell zones) in secondary lymphoid organs, surveying for antigen. After antigen binding, B cells move to the boundary of B and T zones to interact with T-helper cells; this B cell migration is directed by CCR7 and its ligands. CCR7-positive cancer cell expression has been associated with lymph node metastasis.

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