FITC Anti-Human CD196/CCR6 Antibody [G034E3] (AGEL1799)

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SKU:
AGEL1799
Product Type:
Antibody
Antibody Type:
Monoclonal Antibody
Reactivity:
Human
Applications:
FC
Frequently bought together:

Description

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FITC Anti-Human CD196/CCR6 Antibody [G034E3]

The Human CD196 (CCR6) Monoclonal Antibody (FITC-conjugated) is a powerful tool for researchers studying the CCR6 protein, an essential chemokine receptor involved in immune cell migration and immune responses. This monoclonal antibody, tagged with FITC for fluorescent detection, specifically targets human samples and is validated for various applications, including flow cytometry and immunofluorescence.CCR6, a chemokine receptor also known as CD196, plays a crucial role in directing the movement of immune cells to sites of inflammation and infection. Its significance in regulating immune cell trafficking makes it a key focus in research on immune-mediated diseases, such as inflammatory disorders and autoimmune conditions.

By targeting CCR6, researchers can investigate the mechanisms underlying immune cell recruitment and potentially develop targeted therapies for immune-related diseases.The FITC-conjugated Human CD196 (CCR6) Monoclonal Antibody offers reliable and specific detection of CCR6 protein expression in different cell types, providing valuable insights into immune cell behavior and function. Its use in flow cytometry and immunofluorescence assays enables precise visualization and analysis of CCR6-expressing cells, making it an indispensable tool for immunology and inflammation research.

Product Title:FITC Anti-Human CD196/CCR6 Antibody [G034E3]
SKU:AGEL1799
Size:20 Tests, 100 Tests, 200 Tests
Clone No:G034E3
Synonyms:CKRL3; CMKBR6; GPR29; STRL22;GPRCY4;
Host Species:Mouse
Reactivity:Human
Application:FCM
Isotype:Mouse IgG2b, κ
Isotype Control:FITC Mouse IgG2b, κ Isotype Control[MPC-11]
Form:Liquid
Conjugation:FITC
Recommended Use:Each lot of this antibody is quality control tested by flow cytometric analysis. The amount of the reagent is suggested to be used 5 µL of antibody per test (million cells in 100 µL staining volume or per 100 µL of whole blood). Please check your vial before the experiment. Since applications vary, the appropriate dilutions must be determined for individual use.
Spectrum:Spectrum Image
Swissprot:P51684
Gene ID:1235
Storage Buffer:Phosphate buffered solution, pH 7.2, containing 0.09% stabilizer and 1% protein protectant.
Stability & Storage:Keep as concentrated solution. Store at 2~8°C and protected from prolonged exposure to light. Do not freeze. Centrifuge before opening to ensure complete recovery of vial contents. This product is guaranteed up to one year from purchase.
Background:CCR6, also known as CD196/CCR6, is a chemokine receptor that is expressed on immature dendritic cells, B lymphocytes, and memory T cells. CCR6 binds CCL20, although members of the β defensin family also bind CCR6 with a lower affinity. CCR6 positive cells, and its ligand CCL20, have been detected in numerous organs, especially the secondary lymphoid organ. CCL20 is selectively made by the follicle-associated epithelium (FAE) overlying Peyers Patches (PPs) and isolated lymphoid follicles (ILFs). CCL20 contributes to the recruitment of CCR6-expressing B cells to these structures. In humans, CCR6 can function to mediate arrest of T cells on dermal endothelial cells and is highly expressed on T cells resident in both normal and psoriatic skin. CCR6 and/or CCL20 have been implicated in the pathogenesis of rheumatoid arthritis and inflammatory bowel disease. Human T cells that are able to produce IL-17 express CCR6. It suggests that CCL20 and CCR6 have a role in inflammatory diseases by recruiting Th17 cells to target tissues.

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