CD155; commonly known as PVR (poliovirus receptor) and Necl-5 (nectin-like molecule-5); is a type I transmembrane single-span glycoprotein; and belongs to the nectins and nectin-like (Necl) subfamily. CD155 was originally identified based on its ability to mediate the cell attachment and entry of poliovirus (PV); an etiologic agent of the central nervous system disease poliomyelitis. The normal cellular function is in the establishment of intercellular adherens junctions between epithelial cells. CD155 may assist in an efficient humoral immune response generated within the intestinal immune system. It has been demonstrated that CD155 can be recognized and bond by DNAM-1 and CD96 which promote the adhension; migration and NK-cell killing; and thus efficiently prime cell-mediated tumor-specific immunity.Immune CheckpointImmune Checkpoint Detection: ELISA Antibodies Immune Checkpoint Detection: ICC Antibodies Immune Checkpoint Detection: IP Antibodies Immune Checkpoint Detection: FCM Antibodies Immune Checkpoint Detection: WB AntibodiesImmune Checkpoint ProteinsImmune Checkpoint Targets Co-inhibitory Immune Checkpoint Targets Immunotherapy Cancer Immunotherapy Targeted Therapy
Product Name:
Human CD155/PVR Recombinant Protein (RPES0335)
Product Code:
RPES0335
Size:
50µg
Species:
Human
Expressed Host:
HEK293 Cells
Synonyms:
CD155,HVED,Necl-5,NECL5,PVS,TAGE4
Accession:
NP_006496.3
Sequence:
Met 1-Asn 343
Fusion tag:
C-His
Activity:
Measured by its binding ability in a functional ELISA. Immobilized human CD155 at 2 µg/ml (100 ?l/well) can bind human DNAM1 with a linear ranger of 1.28-32 ng/ml.
Endotoxin:
<1.0 EU per µg as determined by the LAL method.
Protein Construction:
A DNA sequence encoding the human CD155 isoform a (NP_006496.3) extracellular domain (Met 1-Asn 343) was fused with a polyhistidine tag at the C-terminus.
Purity:
> 97 % as determined by reducing SDS-PAGE.
Mol Mass:
36.5 kDa
AP Mol Mass:
60-65 kDa
Formulation:
Lyophilized from sterile PBS; pH 7.5
Shipping:
This product is provided as lyophilized powder which is shipped with ice packs.
Stability and Storage:
Lyophilized proteins are stable for up to 12 months when stored at -20 to -80°C. Reconstituted protein solution can be stored at 4-8°C for 2-7 days. Aliquots of reconstituted samples are stable at < -20°C for 3 months.
