The Human CD14 Monoclonal Antibody (FITC Conjugated, M5E2, AGEL2079) is a cutting-edge tool for researchers studying the CD14 protein, a key component of the innate immune system. This monoclonal antibody, labeled with FITC for fluorescence detection, specifically targets human CD14 and is validated for a wide range of applications, including flow cytometry and immunofluorescence. CD14 is a crucial receptor involved in detecting bacterial lipopolysaccharides and initiating immune responses. By targeting CD14, researchers can gain insights into innate immune signaling pathways, inflammatory processes, and infectious disease mechanisms.
This antibody offers high specificity and sensitivity, enabling precise detection and quantification of CD14 in various experimental settings.With its superior performance and reliability, the Human CD14 Monoclonal Antibody (FITC Conjugated, M5E2, AGEL2079) is an invaluable resource for immunologists, microbiologists, and researchers investigating the intricate interplay between the immune system and microbial pathogens. Discover new avenues of research and deepen your understanding of immune responses with this advanced antibody tool.
Each lot of this antibody is quality control tested by flow cytometric analysis. The amount of the reagent is suggested to be used 5 µL of antibody per test (million cells in 100 µL staining volume or per 100 µL of whole blood). Please check your vial before the experiment. Since applications vary, the appropriate dilutions must be determined for individual use.
Spectrum:
Swissprot:
P08571
Gene ID:
929
Storage Buffer:
Phosphate buffered solution, pH 7.2, containing 0.09% stabilizer and 1% protein protectant.
Stability & Storage:
Keep as concentrated solution. Store at 2~8°C and protected from prolonged exposure to light. Do not freeze. Centrifuge before opening to ensure complete recovery of vial contents. This product is guaranteed up to one year from purchase.
Background:
CD14 is a 53-55 kD glycosylphosphatidylinositol (GPI)-linked membrane glycoprotein also known as LPS receptor. CD14 is expressed at high levels on monocytes and macrophages, and at lower levels on granulocytes. Some dendritic cell populations such as interfollicular dendritic cells, reticular dendritic cells, and Langerhans cells have also been reported to express CD14. As a high-affinity receptor for LPS, CD14 is involved in the clearance of gram-negative pathogens, and in the upregulation of adhesion molecules and expression of cytokines in monocytes and neutrophils.