The Human CD134 Monoclonal Antibody FITC Conjugated (BER-ACT35) is a high-quality antibody specifically designed for research purposes involving the CD134 protein, a cell surface molecule known for its role in immune responses and T-cell activation. This monoclonal antibody, conjugated with FITC for fluorescence detection, is validated for use in flow cytometry applications, making it a valuable tool for analyzing and detecting CD134 expression in human samples. CD134, also known as OX40, is a co-stimulatory receptor expressed on activated T cells and plays a crucial role in regulating immune responses and promoting T-cell survival.
Its involvement in modulating T-cell function and cytokine production makes it an important target for studies in immunology, vaccine development, and autoimmune diseases. By targeting CD134, researchers can investigate its impact on immune cell activation and potential therapeutic interventions aimed at modulating immune responses in various disease settings. The Human CD134 Monoclonal Antibody FITC Conjugated (BER-ACT35) offers precise and reliable detection of CD134, making it an essential tool for furthering research in immunology and related fields.
Each lot of this antibody is quality control tested by flow cytometric analysis. The amount of the reagent is suggested to be used 5 µL of antibody per test (million cells in 100 µL staining volume or per 100 µL of whole blood). Please check your vial before the experiment. Since applications vary, the appropriate dilutions must be determined for individual use.
Spectrum:
Swissprot:
P43489
Gene ID:
7293
Storage Buffer:
Phosphate buffered solution, pH 7.2, containing 0.09% stabilizer and 1% protein protectant.
Stability & Storage:
Keep as concentrated solution. Store at 2~8°C and protected from prolonged exposure to light. Do not freeze. Centrifuge before opening to ensure complete recovery of vial contents. This product is guaranteed up to one year from purchase.
Background:
CD134, also known as OX40 and TNFRSF4, is a 50 kD type I transmembrane glycoprotein. It is a member of the TNF receptor family. OX40 is expressed on activated T lymphocytes including Th1, Th2, Th17, and Treg cells. The interaction of OX40 with OX40L results in B cell proliferation and antibody secretion, regulation of primary T cell expansion, and T cell survival. OX40 influences the size of the T cell memory pool and regulation of CD4+ T cell tolerance.