The Human CD122 IL-3RB Monoclonal Antibody (TU27) is a potent tool for researchers interested in studying the CD122 IL-3RB protein, a key receptor involved in immune response regulation. This monoclonal antibody, conjugated with PE for enhanced detection sensitivity, specifically targets the CD122 IL-3RB protein in human samples. CD122 IL-3RB, also known as the interleukin-3 receptor beta subunit, plays a crucial role in mediating cellular responses to interleukin-3, a cytokine important in hematopoiesis and immune function. By targeting this receptor, researchers can gain insights into immune cell activation, proliferation, and differentiation pathways.
This antibody is validated for use in flow cytometry applications, allowing for precise quantification and analysis of CD122 IL-3RB expression in various cell types.Understanding the function of CD122 IL-3RB is instrumental in unraveling the complexities of immune regulation and its dysregulation in diseases such as leukemia, autoimmune disorders, and inflammatory conditions. By utilizing this PE-conjugated monoclonal antibody, researchers can advance their studies in immunology, oncology, and therapeutic development aimed at modulating immune responses for improved treatment strategies.
Each lot of this antibody is quality control tested by flow cytometric analysis. The amount of the reagent is suggested to be used 5 µL of antibody per test (million cells in 100 µL staining volume or per 100 µL of whole blood). Please check your vial before the experiment. Since applications vary, the appropriate dilutions must be determined for individual use.
Spectrum:
Swissprot:
P14784
Gene ID:
3560
Storage Buffer:
Phosphate buffered solution, pH 7.2, containing 0.09% stabilizer and 1% protein protectant.
Stability & Storage:
Keep as concentrated solution. Store at 2~8°C and protected from prolonged exposure to light. Do not freeze. Centrifuge before opening to ensure complete recovery of vial contents. This product is guaranteed up to one year from purchase.
Background:
CD122 is a 70-75 kD type I transmembrane glycoprotein and member of the Ig superfamily. It is IL-2 receptor β chain also known as IL-2Rβ, which is also shared by the IL-15 receptor. CD122 is constitutively expressed by NK cells and at lower levels by a subset of T cells. Its expression is upregulated upon activation. The IL-2Rβ chain can combine with either the common γ subunit (γc, CD132) alone or with the γc subunit and the IL-2Rα subunit (CD25) to generate intermediate or high affinity IL-2 receptor complexes, respectively. CD122 expression levels can be upregulated by activation.
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![PE Anti-Human CD122/IL-2RB Antibody [TU27] (AGEL1780)](https://cdn11.bigcommerce.com/s-39x6lpnvxv/images/stencil/1280x1280/products/122194/120374/AGEL1780__27821__26673.1732015479.jpg?c=1&imbypass=on "PE Anti-Human CD122/IL-2RB Antibody [TU27] (AGEL1780)")
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