The Human CD122 (IL3RB) Monoclonal Antibody (APC-conjugated) (TU27) (AGEL1781) is a cutting-edge tool for researchers studying immune responses and cytokine signaling pathways. This monoclonal antibody, specifically targeting the CD122 (IL3RB) protein, is conjugated with APC for enhanced detection and analysis capabilities.CD122, also known as IL3RB, is a receptor subunit for interleukin-2 (IL-2) and interleukin-15 (IL-15), key cytokines involved in immune cell activation and proliferation. By targeting CD122, researchers can investigate the role of these cytokines in immune function, including T cell activation, differentiation, and survival.This monoclonal antibody is rigorously validated for use in flow cytometry and other immunological techniques, providing reliable and reproducible results.
Its high specificity and sensitivity make it ideal for studies exploring immune responses, cytokine signaling, and potential therapeutic targets in diseases such as cancer, autoimmune disorders, and inflammatory conditions.By utilizing the Human CD122 (IL3RB) Monoclonal Antibody (APC-conjugated) (TU27) (AGEL1781), researchers can gain valuable insights into the intricate mechanisms of immune regulation and cytokine signaling, paving the way for innovative approaches in immunotherapy and disease intervention.
Each lot of this antibody is quality control tested by flow cytometric analysis. The amount of the reagent is suggested to be used 5 µL of antibody per test (million cells in 100 µL staining volume or per 100 µL of whole blood). Please check your vial before the experiment. Since applications vary, the appropriate dilutions must be determined for individual use.
Spectrum:
Swissprot:
P14784
Gene ID:
3560
Storage Buffer:
Phosphate buffered solution, pH 7.2, containing 0.09% stabilizer and 1% protein protectant.
Stability & Storage:
Keep as concentrated solution. Store at 2~8°C and protected from prolonged exposure to light. Do not freeze. Centrifuge before opening to ensure complete recovery of vial contents. This product is guaranteed up to one year from purchase.
Background:
CD122 is a 70-75 kD type I transmembrane glycoprotein and member of the Ig superfamily. It is IL-2 receptor β chain also known as IL-2Rβ, which is also shared by the IL-15 receptor. CD122 is constitutively expressed by NK cells and at lower levels by a subset of T cells. Its expression is upregulated upon activation. The IL-2Rβ chain can combine with either the common γ subunit (γc, CD132) alone or with the γc subunit and the IL-2Rα subunit (CD25) to generate intermediate or high affinity IL-2 receptor complexes, respectively. CD122 expression levels can be upregulated by activation.
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