PE/Cyanine7 Anti-Human CD11b Antibody [ICRF44] (AGEL1754)

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SKU:
AGEL1754
Product Type:
Antibody
Antibody Type:
Monoclonal Antibody
Applications:
FC
Reactivity:
Human
Host Species:
Mouse
Isotype:
IgG2a,k
Clone:
ICRF44
Conjugation:
PE/Cy7
Frequently bought together:

Description

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PE/Cyanine7 Anti-Human CD11b Antibody [ICRF44]

The Human CD11b Monoclonal Antibody (PE/Cyanine7 Conjugated, ICRF44) is a valuable tool for researchers studying immune cell biology and inflammation. This antibody, provided by AssayGenie (AGEL1754), specifically targets the CD11b protein, which is commonly expressed on the surface of various immune cells, including monocytes, macrophages, and granulocytes.The CD11b protein plays a crucial role in adhesion and migration of immune cells, as well as phagocytosis and cytokine secretion. By using this monoclonal antibody conjugated with PE/Cyanine7, researchers can easily detect and analyze CD11b expression in flow cytometry and immunofluorescence experiments in a variety of human samples.

The versatility of this antibody allows for its application in diverse research areas, including immunology, inflammation, infection, and cancer. Understanding the function and regulation of CD11b is essential for elucidating the complex interactions of immune cells in the context of disease and immune response modulation.By employing the Human CD11b Monoclonal Antibody (PE/Cyanine7 Conjugated, ICRF44), researchers can advance their studies in immune system dynamics, inflammatory pathways, and potential therapeutic targets for various immune-related disorders.

Product Title:PE/Cyanine7 Anti-Human CD11b Antibody [ICRF44]
SKU:AGEL1754
Size:20 Tests, 100 Tests, 200 Tests
Clone No:ICRF44
Synonyms:Integrin alpha-M;Itgam;CD11 antigen-like family member B;CR-3 alpha chain;Leukocyte adhesion receptor MO1;CD11b;
Host Species:Mouse
Reactivity:Human
Application:FCM
Isotype:Mouse IgG1, κ
Isotype Control:PE/Cyanine7 Mouse IgG1, κ Isotype Control[MOPC-21]
Form:Liquid
Conjugation:PE/Cyanine 7
Recommended Use:Each lot of this antibody is quality control tested by flow cytometric analysis. The amount of the reagent is suggested to be used 5 µL of antibody per test (million cells in 100 µL staining volume or per 100 µL of whole blood). Please check your vial before the experiment. Since applications vary, the appropriate dilutions must be determined for individual use.
Spectrum:Spectrum Image
Swissprot:P11215
Gene ID:3684
Storage Buffer:Phosphate buffered solution, pH 7.2, containing 0.09% stabilizer and 1% protein protectant.
Stability & Storage:Keep as concentrated solution. Store at 2~8°C and protected from prolonged exposure to light. Do not freeze. Centrifuge before opening to ensure complete recovery of vial contents. This product is guaranteed up to one year from purchase.
Background:CD11b is a 165-170 kD type I transmembrane glycoprotein also known as αMintegrin, Mac-1, CR3, and C3biR. CD11b non-covalently associates with integrin β2(CD18) and is expressed on granulocytes, monocytes/macrophages, dendritic cells, NK cells, and subsets of T and B cells. CD11b/CD18 is critical for the transendothelial migration of monocytes and neutrophils. It is also involved in granulocyte adhesion, phagocytosis, and neutrophil activation. CD11b/CD18 interacts with ICAM-1 (CD54), ICAM-2 (CD102), ICAM-4, CD14, CD23, heparin, iC3b, fibrinogen, and factor X.

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