PE/Cyanine5.5 Anti-Human CD11b Antibody [ICRF44] (AGEL1755)

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SKU:
AGEL1755
Product Type:
Antibody
Antibody Type:
Monoclonal Antibody
Reactivity:
Human
Applications:
FC
Frequently bought together:

Description

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PE/Cyanine5.5 Anti-Human CD11b Antibody [ICRF44]

The Human CD11b Monoclonal Antibody PE-Cyanine5.5 Conjugated (ICRF44) is a powerful tool for researchers studying immune responses and cell signaling pathways. Specifically targeting the CD11b protein, this monoclonal antibody is highly reactive with human samples and is validated for use in flow cytometry applications. Its conjugation with PE-Cyanine5.5 enables precise detection and quantification of CD11b expression in various cell types, making it an ideal choice for immunology and inflammation research.CD11b, also known as integrin alpha-M, plays a key role in mediating cell adhesion and migration, particularly in immune cells such as neutrophils, monocytes, and macrophages.

Its involvement in inflammatory processes and immune cell activation highlights its importance in conditions like infections, autoimmune diseases, and tissue injury. By targeting CD11b with this monoclonal antibody, researchers can gain insights into the mechanisms underlying immune cell function and identify potential therapeutic targets for immune-related disorders.

Product Title:PE/Cyanine5.5 Anti-Human CD11b Antibody [ICRF44]
SKU:AGEL1755
Size:20 Tests, 100 Tests, 200 Tests
Clone No:ICRF44
Synonyms:Integrin alpha-M;Itgam;CD11 antigen-like family member B;CR-3 alpha chain;Leukocyte adhesion receptor MO1;CD11b;
Host Species:Mouse
Reactivity:Human
Application:FCM
Isotype:Mouse IgG1, κ
Isotype Control:PE/Cyanine5.5 Mouse IgG1, κ Isotype Control[MOPC-21]
Form:Liquid
Conjugation:PE/Cyanine 5.5
Recommended Use:Each lot of this antibody is quality control tested by flow cytometric analysis. The amount of the reagent is suggested to be used 5 µL of antibody per test (million cells in 100 µL staining volume or per 100 µL of whole blood). Please check your vial before the experiment. Since applications vary, the appropriate dilutions must be determined for individual use.
Spectrum:Spectrum Image
Swissprot:P11215
Gene ID:3684
Storage Buffer:Phosphate buffered solution, pH 7.2, containing 0.09% stabilizer and 1% protein protectant.
Stability & Storage:Keep as concentrated solution. Store at 2~8°C and protected from prolonged exposure to light. Do not freeze. Centrifuge before opening to ensure complete recovery of vial contents. This product is guaranteed up to one year from purchase.
Background:CD11b is a 165-170 kD type I transmembrane glycoprotein also known as αMintegrin, Mac-1, CR3, and C3biR. CD11b non-covalently associates with integrin β2(CD18) and is expressed on granulocytes, monocytes/macrophages, dendritic cells, NK cells, and subsets of T and B cells. CD11b/CD18 is critical for the transendothelial migration of monocytes and neutrophils. It is also involved in granulocyte adhesion, phagocytosis, and neutrophil activation. CD11b/CD18 interacts with ICAM-1 (CD54), ICAM-2 (CD102), ICAM-4, CD14, CD23, heparin, iC3b, fibrinogen, and factor X.

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