Human CBR3 Recombinant Protein (RPPB1476)

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SKU:
RPPB1476
Product type:
Recombinant Protein
Size:
20ug
Species:
Human
Target:
CBR3
Synonyms:
Carbonyl reductase [NADPH] 3
Synonyms:
NADPH-dependent carbonyl reductase 3
Synonyms:
CBR3
Synonyms:
carbonyl reductase 3
Source:
Escherichia Coli
Uniprot:
O75828
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Description

Product Name:Human CBR3 Recombinant Protein
Product Code:RPPB1476
Size:20µg
Species:Human
Target:CBR3
Synonyms:Carbonyl reductase [NADPH] 3, NADPH-dependent carbonyl reductase 3, CBR3, carbonyl reductase 3, hCBR3, SDR21C2.
Source:Escherichia Coli
Physical Appearance:Sterile filtered colorless solution.
Formulation:The CBR3 protein solution (1mg/ml) contains 20mM Tris-HCl buffer (pH 8.0) and 10% glycerol.
Stability:Store at 4°C if entire vial will be used within 2-4 weeks. Store, frozen at -20°C for longer periods of time. For long term storage it is recommended to add a carrier protein (0.1% HSA or BSA). Avoid multiple freeze-thaw cycles.
Purity:Greater than 95.0% as determined by analysis by SDS-PAGE.
Amino Acid Sequence:MGSSHHHHHH SSGLVPRGSH MSSCSRVALV TGANRGIGLA IARELCRQFS GDVVLTARDV ARGQAAVQQL QAEGLSPRFH QLDIDDLQSI RALRDFLRKE YGGLNVLVNN AAVAFKSDDP MPFDIKAEMT LKTNFFATRN MCNELLPIMK PHGRVVNISS LQCLRAFENC SEDLQERFHS ETLTEGDLVD LMKKFVEDTK NEVHEREGWP NSPYGVSKLG VTVLSRILAR RLDEKRKADR ILVNACCPGP VKTDMDGKDS IRTVEEGAET PVYLALLPPD ATEPQGQLVH DKVVQNW

CBR3 catalyzes the reduction of a large number of biologically and pharmacologically active carbonyl compounds to their corresponding alcohols. CBR3 is one of several monomeric NADPH-dependent oxidoreductases. Furthermore, CBR3 contains 3 exons spanning 11.2 kilobases and is strongly linked to another carbonyl reductase gene, the CBR1. It was suggested that CBR3 mediates 9-cis-retinoic acid-induced cytostatis and is a potential prognostic marker for oral malignancy.CBR3 is identified in the ovary, pancreas, intestine, colon, kidney, brain, thymus, lung, heart, liver, spleen, leukocyte, prostate and the testis.

Recombinant Human CBR3 fused with a 20 amino acid His tag at N-terminus produced in E.Coli is a single, non-glycosylated polypeptide chain containing 297 amino acids (1-277 a.a) and having a molecular mass of 33kDa. CBR3 is purified by proprietary chromatographic techniques.

UniProt Protein Function:CBR3: Has low NADPH-dependent oxidoreductase activity towards 4-benzoylpyridine and menadione (in vitro). Belongs to the short-chain dehydrogenases/reductases (SDR) family.
UniProt Protein Details:

Protein type:Oxidoreductase; Lipid Metabolism - arachidonic acid; EC 1.1.1.184

Chromosomal Location of Human Ortholog: 21q22.2

Cellular Component: cytoplasm; cytosol; extracellular space; nucleoplasm

Molecular Function:3-keto sterol reductase activity; carbonyl reductase (NADPH) activity

Biological Process: cognition; phylloquinone catabolic process

NCBI Summary:Carbonyl reductase 3 catalyzes the reduction of a large number of biologically and pharmacologically active carbonyl compounds to their corresponding alcohols. The enzyme is classified as a monomeric NADPH-dependent oxidoreductase. CBR3 contains three exons spanning 11.2 kilobases and is closely linked to another carbonyl reductase gene - CBR1. [provided by RefSeq, Jul 2008]
UniProt Code:O75828
NCBI GenInfo Identifier:6014959
NCBI Gene ID:874
NCBI Accession:O75828.3
UniProt Secondary Accession:O75828,Q6FHP2,
UniProt Related Accession:O75828
Molecular Weight:30,850 Da
NCBI Full Name:Carbonyl reductase
NCBI Synonym Full Names:carbonyl reductase 3
NCBI Official Symbol:CBR3  
NCBI Official Synonym Symbols:hCBR3; SDR21C2; HEL-S-25  
NCBI Protein Information:carbonyl reductase [NADPH] 3
UniProt Protein Name:Carbonyl reductase [NADPH] 3
UniProt Synonym Protein Names:NADPH-dependent carbonyl reductase 3; Short chain dehydrogenase/reductase family 21C member 2
Protein Family:Carbonyl reductase
UniProt Gene Name:CBR3  
UniProt Entry Name:CBR3_HUMAN
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