Human CBFB HUman Recombinant Protein (RPPB2987)

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SKU:
RPPB2987
Product type:
Recombinant Protein
Size:
10ug
Species:
Human
Target:
CBFB HUman
Synonyms:
PEBP2B
Synonyms:
polyomavirus enhancer binding protein b
Synonyms:
PEA2
Synonyms:
CBF-beta
Source:
Escherichia Coli
Uniprot:
Q13951
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Description

Product Name:Human CBFB HUman Recombinant Protein
Product Code:RPPB2987
Size:10µg
Species:Human
Target:CBFB HUman
Synonyms:PEBP2B, polyomavirus enhancer binding protein b, PEA2, CBF-beta.
Source:Escherichia Coli
Physical Appearance:Sterile filtered colorless solution.
Formulation:0.5mg/ml solution containing 20mM MES pH-6, 0.1mM PMSF & 10% glycerol.
Stability:CBFB Human although stable at 4C for 1 week, should be stored below -18C. Please prevent freeze thaw cycles.
Purity:Greater than 85.0% as determined by SDS-PAGE.
Amino Acid Sequence:MGSSHHHHHH SSGLVPRGSH MPRVVPDQRS KFENEEFFRK LSRECEIKYT GFRDRPHEER QARFQNACRD GRSEIAFVAT GTNLSLQFFPASWQGEQRQT PSREYVDLER EAGKVYLKAP MILNGVCVIW KGWIDLQRLD GMGCLEFDEE RAQQEDALAQ QAFEEARRRT REFEDRDRSHREEMEVRVSQ LLAVTGKKTT RP

CBFB beta subunit is a heterodimeric core-binding transcription factor that is part of the PEBP2/CBF transcription factor family which controls a host of genes particulary to hematopoiesis and osteogenesis. CBFB is a non-DNA binding regulatory subunit which increases DNA binding by alpha subunit.

CBFB Recombinant Human produced in E.Coli is a single, non-glycosylated polypeptide chain containing 182 amino acids (1-202 a.a.) and having a molecular mass of 23.6 kDa. The CBFB is fused to 20 amino acid His-Tag at N-terminus and purified by proprietary chromatographic techniques.

UniProt Protein Function:CBFB: CBF binds to the core site, 5'-PYGPYGGT-3', of a number of enhancers and promoters, including murine leukemia virus, polyomavirus enhancer, T-cell receptor enhancers, LCK, IL3 and GM- CSF promoters. CBFB enhances DNA binding by RUNX1. A chromosomal aberration involving CBFB is associated with acute myeloid leukemia of M4EO subtype. Pericentric inversion inv(16)(p13;q22). The inversion produces a fusion protein that consists of the 165 N-terminal residues of CBF-beta (PEPB2) with the tail region of MYH11. Belongs to the CBF-beta family. 2 isoforms of the human protein are produced by alternative splicing.
UniProt Protein Details:

Protein type:Transcription factor; Oncoprotein; DNA-binding

Chromosomal Location of Human Ortholog: 16q22.1

Cellular Component: membrane; nucleus

Molecular Function:protein binding; DNA binding; transcription coactivator activity; transcription factor activity

Biological Process: transcription from RNA polymerase II promoter; osteoblast differentiation; lymphocyte differentiation; cell maturation; myeloid cell differentiation; positive regulation of transcription from RNA polymerase II promoter

NCBI Summary:The protein encoded by this gene is the beta subunit of a heterodimeric core-binding transcription factor belonging to the PEBP2/CBF transcription factor family which master-regulates a host of genes specific to hematopoiesis (e.g., RUNX1) and osteogenesis (e.g., RUNX2). The beta subunit is a non-DNA binding regulatory subunit; it allosterically enhances DNA binding by alpha subunit as the complex binds to the core site of various enhancers and promoters, including murine leukemia virus, polyomavirus enhancer, T-cell receptor enhancers and GM-CSF promoters. Alternative splicing generates two mRNA variants, each encoding a distinct carboxyl terminus. In some cases, a pericentric inversion of chromosome 16 [inv(16)(p13q22)] produces a chimeric transcript consisting of the N terminus of core-binding factor beta in a fusion with the C-terminal portion of the smooth muscle myosin heavy chain 11. This chromosomal rearrangement is associated with acute myeloid leukemia of the M4Eo subtype. Two transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Jul 2008]
UniProt Code:Q13951
NCBI GenInfo Identifier:2498753
NCBI Gene ID:865
NCBI Accession:Q13951.2
UniProt Secondary Accession:Q13951,Q13124, Q9HCT2, A8K347,
UniProt Related Accession:Q13951
Molecular Weight:21,991 Da
NCBI Full Name:Core-binding factor subunit beta
NCBI Synonym Full Names:core-binding factor, beta subunit
NCBI Official Symbol:CBFB  
NCBI Official Synonym Symbols:PEBP2B  
NCBI Protein Information:core-binding factor subunit beta; CBF-beta; PEA2-beta; PEBP2-beta; SL3-3 enhancer factor 1 beta subunit; SL3-3 enhancer factor 1 subunit beta; SL3/AKV core-binding factor beta subunit; polyomavirus enhancer-binding protein 2 beta subunit; polyomavirus enhancer binding protein 2, beta subunit
UniProt Protein Name:Core-binding factor subunit beta
UniProt Synonym Protein Names:Polyomavirus enhancer-binding protein 2 beta subunit; PEA2-beta; PEBP2-beta; SL3-3 enhancer factor 1 subunit beta; SL3/AKV core-binding factor beta subunit
Protein Family:Core-binding factor
UniProt Gene Name:CBFB  
UniProt Entry Name:PEBB_HUMAN
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