Human CAMK4 Recombinant Protein (RPPB2447)
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주문- SKU:
- RPPB2447
- Product type:
- Recombinant Protein
- Size:
- 10ug
- Species:
- Human
- Target:
- CAMK4
- Synonyms:
- Calcium/calmodulin-dependent protein kinase type IV catalytic chain
- Synonyms:
- CaMK-GR
- Synonyms:
- CaM kinase-GR
- Synonyms:
- CaMK IV
- Source:
- Escherichia Coli
- Uniprot:
- Q16566
Description
| Product Name: | Human CAMK4 Recombinant Protein |
| Product Code: | RPPB2447 |
| Size: | 10µg |
| Species: | Human |
| Target: | CAMK4 |
| Synonyms: | Calcium/calmodulin-dependent protein kinase type IV catalytic chain, CaMK-GR, CaM kinase-GR, CaMK IV, IV, brain Ca(2+)-calmodulin-dependent protein kinase type IV, caMK, CAM kinase IV, EC 2.7.11.17. |
| Source: | Escherichia Coli |
| Physical Appearance: | Sterile Filtered colorless solution. |
| Formulation: | The CAMK4 solution (0.5mg/ml) contains 20mM Tris-HCl buffer (pH 8.0), 100mM NaCl and 10% glycerol. |
| Stability: | Store at 4°C if entire vial will be used within 2-4 weeks. Store, frozen at -20°C for longer periods of time. For long term storage it is recommended to add a carrier protein (0.1% HSA or BSA).Avoid multiple freeze-thaw cycles. |
| Purity: | Greater than 85% as determined by SDS-PAGE. |
| Amino Acid Sequence: | MGSSHHHHHH SSGLVPRGSH MGSHMLKVTV PSCSASSCSS VTASAAPGTA SLVPDYWIDG SNRDALSDFF EVESELGRGA TSIVYRCKQK GTQKPYALKV LKKTVDKKIV RTEIGVLLRL SHPNIIKLKE IFETPTEISL VLELVTGGEL FDRIVEKGYY SERDAADAVK QILEAVAYLH ENGIVHRDLK PENLLYATPA PDAPLKIADF GLSKIVEHQV LMKTVCGTPG YCAPEILRGC AYGPEVDMWS VGIITYILLC GFEPFYDERG DQFMFRRILN CEYYFISPWW DEVSLNAKDL VRKLIVLDPK KRLTTFQALQ HPWVTGKAAN FVHMDTAQKK LQEFNARRKL KAAVKAVVAS SRLGSASSSH GSIQESHKAS RDPSPIQDGN EDMKAIPEGE KIQGDGAQAA VKGAQAELMK VQALEKVKGA DINAEEAPKM VPKAVEDGIK VADLELEEGL AEEKLKTVEE AAAPREGQGS SAVGFEVPQQ DVILPEY |
CAMK4 is a member of the serine/threonine protein kinase family, and of the Ca(2+)/calmodulin-dependent protein kinase subfamily. CAMK4 is a multifunctional serine/threonine protein kinase with restricted tissue distribution which is associated to transcriptional regulation in lymphocytes, neurons and male germ cells.
CAMK4 Human Recombinant produced in E.coli is a single, non-glycosylated polypeptide chain containing 497 amino acids (1-473) and having a molecular mass of 54.5kDa.CAMK4 is fused to a 24 amino acid His-tag at N-terminus & purified by proprietary chromatographic techniques.
| UniProt Protein Function: | CAMK4: a protein kinase of the CAMK1 family. Implicated in transcriptional regulation in lymphocytes, neurons and male germ cells. Two alternatively sliced isoforms have been described. |
| UniProt Protein Details: | Protein type:Protein kinase, Ser/Thr (non-receptor); Protein kinase, CAMK; EC 2.7.11.17; Kinase, protein; CAMK group; CAMK1 family Chromosomal Location of Human Ortholog: 5q21.3 Cellular Component: cytoplasm; cytosol; nucleolus; nucleoplasm Molecular Function:ATP binding; calcium-dependent protein serine/threonine kinase activity; calmodulin binding; calmodulin-dependent protein kinase activity Biological Process: adaptive immune response; epidermal growth factor receptor signaling pathway; fibroblast growth factor receptor signaling pathway; inflammatory response; innate immune response; long-term memory; myeloid dendritic cell cytokine production; myeloid dendritic cell differentiation; nerve growth factor receptor signaling pathway; nerve-nerve synaptic transmission; nucleocytoplasmic transport; peptidyl-serine phosphorylation; phospholipase C activation; positive regulation of protein export from nucleus; positive regulation of transcription, DNA-dependent; protein amino acid autophosphorylation; protein amino acid phosphorylation; regulation of osteoclast differentiation; regulation of T cell differentiation in the thymus; signal transduction; synaptic transmission |
| NCBI Summary: | The product of this gene belongs to the serine/threonine protein kinase family, and to the Ca(2+)/calmodulin-dependent protein kinase subfamily. This enzyme is a multifunctional serine/threonine protein kinase with limited tissue distribution, that has been implicated in transcriptional regulation in lymphocytes, neurons and male germ cells. [provided by RefSeq, Jul 2008] |
| UniProt Code: | Q16566 |
| NCBI GenInfo Identifier: | 2499586 |
| NCBI Gene ID: | 814 |
| NCBI Accession: | Q16566.1 |
| UniProt Secondary Accession: | Q16566,D3DSZ7, |
| UniProt Related Accession: | Q16566 |
| Molecular Weight: | 51,926 Da |
| NCBI Full Name: | Calcium/calmodulin-dependent protein kinase type IV |
| NCBI Synonym Full Names: | calcium/calmodulin-dependent protein kinase IV |
| NCBI Official Symbol: | CAMK4 |
| NCBI Official Synonym Symbols: | caMK; CaMK IV; CaMK-GR |
| NCBI Protein Information: | calcium/calmodulin-dependent protein kinase type IV |
| UniProt Protein Name: | Calcium/calmodulin-dependent protein kinase type IV |
| UniProt Synonym Protein Names: | CaM kinase-GR |
| Protein Family: | Calcium/calmodulin-dependent protein kinase |
| UniProt Gene Name: | CAMK4 |
| UniProt Entry Name: | KCC4_HUMAN |
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