Human Calumenin Recombinant Protein (RPPB2972)
- SKU:
- RPPB2972
- Product type:
- Recombinant Protein
- Size:
- 10ug
- Species:
- Human
- Target:
- Calumenin
- Synonyms:
- CALU
- Crocalbin
- IEF SSP 9302
- FLJ90608
- Source:
- Escherichia Coli
- Uniprot:
- O43852
Description
| Product Name: | Human Calumenin Recombinant Protein |
| Product Code: | RPPB2972 |
| Size: | 10µg |
| Species: | Human |
| Target: | Calumenin |
| Synonyms: | CALU, Crocalbin, IEF SSP 9302, FLJ90608, Calumenin. |
| Source: | Escherichia Coli |
| Physical Appearance: | Sterile Filtered clear solution. |
| Formulation: | The Calumenin solution (0.5mg/1ml) contains phosphate buffered saline (pH7.4) and 10% glycerol. |
| Stability: | Store at 4°C if entire vial will be used within 2-4 weeks. Store, frozen at -20°C for longer periods of time. For long term storage it is recommended to add a carrier protein (0.1% HSA or BSA).Avoid multiple freeze-thaw cycles. |
| Purity: | Greater than 90.0% as determined by SDS-PAGE. |
| Amino Acid Sequence: | MKPTEKKDRV HHEPQLSDKV HNDAQSFDYD HDAFLGAEEA KTFDQLTPEE SKERLGKIVS KIDGDKDGFV TVDELKDWIK FAQKRWIYED VERQWKGHDL NEDGLVSWEE YKNATYGYVL DDPDPDDGFN YKQMMVRDER RFKMADKDGD LIATKEEFTA FLHPEEYDYM KDIVVQETME DIDKNADGFI DLEEYIGDMY SHDGNTDEPE WVKTEREQFV EFRDKNRDGK MDKEETKDWI LPSDYDHAEA EARHLVYESD QNKDGKLTKE EIVDKYDLFV GSQATDFGEA LVRHDEF |
| Biological Activity: | The IC50 value is < 2.0nM. The inhibitory function of Cystatin 5 on protease activity of papain was measured by a fluorometric assay using Z-FR-AMC at pH 7.5 at 25C. |
Calumenin is a calcium-binding protein located in the endoplasmic reticulum (ER) and sarcoplasmic reticulum (SR) of mammalian tissues which plays a role in ER functions as protein folding and sorting. Calumenin belongs to a family of multiple EF-hand proteins (CERC) that include reticulocalbin, ERC-55, and Cab45 and the product of this gene. Calumenin binds 7 calcium ions having low affinity and takes part in such ER functions as protein folding and sorting.
Calumenin Human Recombinant produced in E. coli is a single polypeptide chain containing 297 amino acids (20-315) and having a molecular mass of 35kDa. Calumenin is purified by proprietary chromatographic techniques.
| UniProt Protein Function: | CALU: Involved in regulation of vitamin K-dependent carboxylation of multiple N-terminal glutamate residues. Seems to inhibit gamma-carboxylase GGCX. Binds 7 calcium ions with a low affinity. Belongs to the CREC family. 4 isoforms of the human protein are produced by alternative splicing. |
| UniProt Protein Details: | Protein type:Calcium-binding; Secreted; Secreted, signal peptide Chromosomal Location of Human Ortholog: 7q32.1 Cellular Component: endoplasmic reticulum; membrane Molecular Function:calcium ion binding; protein binding |
| NCBI Summary: | The product of this gene is a calcium-binding protein localized in the endoplasmic reticulum (ER) and it is involved in such ER functions as protein folding and sorting. This protein belongs to a family of multiple EF-hand proteins (CERC) that include reticulocalbin, ERC-55, and Cab45 and the product of this gene. Alternatively spliced transcript variants encoding different isoforms have been identified. [provided by RefSeq, Oct 2008] |
| UniProt Code: | O43852 |
| NCBI GenInfo Identifier: | 5921197 |
| NCBI Gene ID: | 813 |
| NCBI Accession: | O43852.2 |
| UniProt Secondary Accession: | O43852,B3KPG9, D6QS48, D6QS49, D6QS50, D6QS51, D6QS52 D6QS53, D6QS54, D6QS55, D6QS56, D6QS57, |
| UniProt Related Accession: | O43852 |
| Molecular Weight: | 37kDa |
| NCBI Full Name: | Calumenin |
| NCBI Synonym Full Names: | calumenin |
| NCBI Official Symbol: | CALU |
| NCBI Protein Information: | calumenin |
| UniProt Protein Name: | Calumenin |
| UniProt Synonym Protein Names: | Crocalbin; IEF SSP 9302 |
| Protein Family: | Calumenin |
| UniProt Gene Name: | CALU |
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