Human Calumenin Recombinant Protein (RPPB2972)

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SKU:
RPPB2972
Product type:
Recombinant Protein
Size:
10ug
Species:
Human
Target:
Calumenin
Synonyms:
CALU
Synonyms:
Crocalbin
Synonyms:
IEF SSP 9302
Synonyms:
FLJ90608
Source:
Escherichia Coli
Uniprot:
O43852
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Description

Product Name:Human Calumenin Recombinant Protein
Product Code:RPPB2972
Size:10µg
Species:Human
Target:Calumenin
Synonyms:CALU, Crocalbin, IEF SSP 9302, FLJ90608, Calumenin.
Source:Escherichia Coli
Physical Appearance:Sterile Filtered clear solution.
Formulation:The Calumenin solution (0.5mg/1ml) contains phosphate buffered saline (pH7.4) and 10% glycerol.
Stability:Store at 4°C if entire vial will be used within 2-4 weeks. Store, frozen at -20°C for longer periods of time. For long term storage it is recommended to add a carrier protein (0.1% HSA or BSA).Avoid multiple freeze-thaw cycles.
Purity:Greater than 90.0% as determined by SDS-PAGE.
Amino Acid Sequence:MKPTEKKDRV HHEPQLSDKV HNDAQSFDYD HDAFLGAEEA KTFDQLTPEE SKERLGKIVS KIDGDKDGFV TVDELKDWIK FAQKRWIYED VERQWKGHDL NEDGLVSWEE YKNATYGYVL DDPDPDDGFN YKQMMVRDER RFKMADKDGD LIATKEEFTA FLHPEEYDYM KDIVVQETME DIDKNADGFI DLEEYIGDMY SHDGNTDEPE WVKTEREQFV EFRDKNRDGK MDKEETKDWI LPSDYDHAEA EARHLVYESD QNKDGKLTKE EIVDKYDLFV GSQATDFGEA LVRHDEF
Biological Activity:The IC50 value is < 2.0nM. The inhibitory function of Cystatin 5 on protease activity of papain was measured by a fluorometric assay using Z-FR-AMC at pH 7.5 at 25C.

Calumenin is a calcium-binding protein located in the endoplasmic reticulum (ER) and sarcoplasmic reticulum (SR) of mammalian tissues which plays a role in ER functions as protein folding and sorting. Calumenin belongs to a family of multiple EF-hand proteins (CERC) that include reticulocalbin, ERC-55, and Cab45 and the product of this gene. Calumenin binds 7 calcium ions having low affinity and takes part in such ER functions as protein folding and sorting.

Calumenin Human Recombinant produced in E. coli is a single polypeptide chain containing 297 amino acids (20-315) and having a molecular mass of 35kDa. Calumenin is purified by proprietary chromatographic techniques.

UniProt Protein Function:CALU: Involved in regulation of vitamin K-dependent carboxylation of multiple N-terminal glutamate residues. Seems to inhibit gamma-carboxylase GGCX. Binds 7 calcium ions with a low affinity. Belongs to the CREC family. 4 isoforms of the human protein are produced by alternative splicing.
UniProt Protein Details:

Protein type:Calcium-binding; Secreted; Secreted, signal peptide

Chromosomal Location of Human Ortholog: 7q32.1

Cellular Component: endoplasmic reticulum; membrane

Molecular Function:calcium ion binding; protein binding

NCBI Summary:The product of this gene is a calcium-binding protein localized in the endoplasmic reticulum (ER) and it is involved in such ER functions as protein folding and sorting. This protein belongs to a family of multiple EF-hand proteins (CERC) that include reticulocalbin, ERC-55, and Cab45 and the product of this gene. Alternatively spliced transcript variants encoding different isoforms have been identified. [provided by RefSeq, Oct 2008]
UniProt Code:O43852
NCBI GenInfo Identifier:5921197
NCBI Gene ID:813
NCBI Accession:O43852.2
UniProt Secondary Accession:O43852,B3KPG9, D6QS48, D6QS49, D6QS50, D6QS51, D6QS52 D6QS53, D6QS54, D6QS55, D6QS56, D6QS57,
UniProt Related Accession:O43852
Molecular Weight:37kDa
NCBI Full Name:Calumenin
NCBI Synonym Full Names:calumenin
NCBI Official Symbol:CALU  
NCBI Protein Information:calumenin
UniProt Protein Name:Calumenin
UniProt Synonym Protein Names:Crocalbin; IEF SSP 9302
Protein Family:Calumenin
UniProt Gene Name:CALU  
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