Human Calumenin Recombinant Protein (RPPB2971)
- SKU:
- RPPB2971
- Product type:
- Recombinant Protein
- Size:
- 25ug
- Species:
- Human
- Target:
- Calumenin
- Synonyms:
- CALU
- Crocalbin
- IEF SSP 9302
- FLJ90608
- Source:
- Escherichia Coli
- Uniprot:
- O43852
Description
| Product Name: | Human Calumenin Recombinant Protein |
| Product Code: | RPPB2971 |
| Size: | 25µg |
| Species: | Human |
| Target: | Calumenin |
| Synonyms: | CALU, Crocalbin, IEF SSP 9302, FLJ90608, Calumenin. |
| Source: | Escherichia Coli |
| Physical Appearance: | Sterile filtered colorless solution. |
| Formulation: | The Calumenin protein contains 20mM Tris-HCl buffer pH-8 and 10% glycerol. |
| Stability: | Store at 4°C if entire vial will be used within 2-4 weeks. Store, frozen at -20°C for longer periods of time. For long term storage it is recommended to add a carrier protein (0.1% HSA or BSA). Avoid multiple freeze-thaw cycles. |
| Purity: | Greater than 90% as determined by Analysis by SDS-PAGE. |
| Amino Acid Sequence: | MGSSHHHHHH SSGLVPRGSH MKPTEKKDRV HHEPQLSDKV HNDAQSFDYD HDAFLGAEEA KTFDQLTPEE SKERLGKIVS KIDGDKDGFV TVDELKDWIK FAQKRWIYED VERQWKGHDL NEDGLVSWEE YKNATYGYVL DDPDPDDGFN YKQMMVRDER RFKMADKDGD LIATKEEFTA FLHPEEYDYM KDIVVQETME DIDKNADGFI DLEEYIGDMY SHDGNTDEPE WVKTEREQFV EFRDKNRDGK MDKEETKDWI LPSDYDHAEA EARHLVYESD QNKDGKLTKE EIVDKYDLFV GSQATDFGEA LVRHDEF |
Calumenin is a calcium-binding protein located in the endoplasmic reticulum (ER) and sarcoplasmic reticulum (SR) of mammalian tissues which plays a role in ER functions as protein folding and sorting. Calumenin belongs to a family of multiple EF-hand proteins (CERC) that include reticulocalbin, ERC-55, and Cab45 and the product of this gene. Calumenin binds 7 calcium ions having low affinity and takes part in such ER functions as protein folding and sorting.
Recombinant Human Calumenin produced in E.Coli is a single, non-glycosylated polypeptide chain containing 317 amino acids (20-315 a.a) and having a molecular mass of 37.2 kDa. Calumenin is fused to a 20 amino acid His Tag at N-terminus and purified by proprietary chromatographic techniques.
| UniProt Protein Function: | CALU: Involved in regulation of vitamin K-dependent carboxylation of multiple N-terminal glutamate residues. Seems to inhibit gamma-carboxylase GGCX. Binds 7 calcium ions with a low affinity. Belongs to the CREC family. 4 isoforms of the human protein are produced by alternative splicing. |
| UniProt Protein Details: | Protein type:Calcium-binding; Secreted; Secreted, signal peptide Chromosomal Location of Human Ortholog: 7q32.1 Cellular Component: endoplasmic reticulum; membrane Molecular Function:calcium ion binding; protein binding |
| NCBI Summary: | The product of this gene is a calcium-binding protein localized in the endoplasmic reticulum (ER) and it is involved in such ER functions as protein folding and sorting. This protein belongs to a family of multiple EF-hand proteins (CERC) that include reticulocalbin, ERC-55, and Cab45 and the product of this gene. Alternatively spliced transcript variants encoding different isoforms have been identified. [provided by RefSeq, Oct 2008] |
| UniProt Code: | O43852 |
| NCBI GenInfo Identifier: | 5921197 |
| NCBI Gene ID: | 813 |
| NCBI Accession: | O43852.2 |
| UniProt Secondary Accession: | O43852,B3KPG9, D6QS48, D6QS49, D6QS50, D6QS51, D6QS52 D6QS53, D6QS54, D6QS55, D6QS56, D6QS57, |
| UniProt Related Accession: | O43852 |
| Molecular Weight: | 37kDa |
| NCBI Full Name: | Calumenin |
| NCBI Synonym Full Names: | calumenin |
| NCBI Official Symbol: | CALU |
| NCBI Protein Information: | calumenin |
| UniProt Protein Name: | Calumenin |
| UniProt Synonym Protein Names: | Crocalbin; IEF SSP 9302 |
| Protein Family: | Calumenin |
| UniProt Gene Name: | CALU |
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