Human CACYBP Recombinant Protein (RPPB5863)

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주문
SKU:
RPPB5863
Product type:
Recombinant Protein
Size:
25ug
Species:
Human
Target:
CACYBP
Synonyms:
S100A6BP
Synonyms:
S100A6 Binding Protein
Synonyms:
GIG5
Synonyms:
PNAS-107
Source:
Escherichia Coli
Uniprot:
Q9HB71
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Description

Product Name:Human CACYBP Recombinant Protein
Product Code:RPPB5863
Size:25µg
Species:Human
Target:CACYBP
Synonyms:S100A6BP, S100A6 Binding Protein, GIG5, PNAS-107, RP1-102G20.6, SIP, CACYBP, hCacyBP, Siah-interacting protein, MGC87971.
Source:Escherichia Coli
Physical Appearance:Sterile filtered colorless solution.
Formulation:CACYBP Human solution containing 20mM Tris HCL pH-8, 1mM DTT, 0.1M NaCl & 10% glycerol.
Stability:Store at 4°C if entire vial will be used within 2-4 weeks. Store, frozen at -20°C for longer periods of time. For long term storage it is recommended to add a carrier protein (0.1% HSA or BSA).Avoid multiple freeze-thaw cycles.
Purity:Greater than 85% as determined by SDS-PAGE.
Amino Acid Sequence:MGSSHHHHHH SSGLVPRGSH MQQKSQKKAE LLDNEKPAAV VAPITTGYTV KISNYGWDQS DKFVKIYITL TGVHQVPTEN VQVHFTERSF DLLVKNLNGK SYSMIVNNLL KPISVEGSSK KVKTDTVLIL CRKKVENTRW DYLTQVEKEC KEKEKPSYDT ETDPSEGLMN VLKKIYEDGD DDMKRTINKA WVESREKQAK GDTEF

CACYBP (calcyclin binding protein) participates in calcium-dependent ubiquitination and subsequent proteosomal degradation of target proteins. CACYBP acts as a molecular bridge in ubiquitin E3 complexes. CACYBP is involved in the ubiquitin-mediated degradation of beta-catenin.

CACYBP Human Recombinant produced in E.Coli is a single, non-glycosylated,polypeptide chain containing 205 amino acids (1-185a.a.) and having a molecular mass of 23.4 kDa. CACYBP protein is fused to a 20 amino acid His tag at N-terminus and is purified by standard chromatography.

UniProt Protein Function:CACYBP: a nuclear/cytoplasmic protein involved in calcium-dependent ubiquitination and proteosomal degradation of target proteins. A possible molecular bridge in ubiquitin E3 complexes. Participates in the ubiquitin-mediated degradation of beta-catenin (CTNNB1). Interacts with proteins of the S100 family at physiological calcium concentrations. Component of some large E3 complexes and interacts directly with SIAH1, SIAH2 and SKP1A. Cytoplasmic at low calcium concentrations. In neuroblastoma cells, after a retinoic acid (RA) induction and calcium increase, it localizes in both the nucleus and cytoplasm. The nuclear fraction may be phosphorylated. Two alternatively spliced isoforms have been described.
UniProt Protein Details:

Protein type:Adaptor/scaffold; Ubiquitin conjugating system

Chromosomal Location of Human Ortholog: 1q24-q25

Cellular Component: nucleoplasm; neuron projection; nuclear envelope lumen; cytoplasm; beta-catenin destruction complex

Molecular Function:protein binding; protein homodimerization activity

Biological Process: positive regulation of DNA replication; cardiac muscle cell differentiation; aging

NCBI Summary:The protein encoded by this gene is a calcyclin binding protein. It may be involved in calcium-dependent ubiquitination and subsequent proteosomal degradation of target proteins. It probably serves as a molecular bridge in ubiquitin E3 complexes and participates in the ubiquitin-mediated degradation of beta-catenin. Two alternatively spliced transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Jul 2008]
UniProt Code:Q9HB71
NCBI GenInfo Identifier:46576651
NCBI Gene ID:27101
NCBI Accession:Q9HB71.2
UniProt Secondary Accession:Q9HB71,O60666, Q5R370, Q5R371, B2ZWH2, B3KSF1,
UniProt Related Accession:Q9HB71
Molecular Weight:21,228 Da
NCBI Full Name:Calcyclin-binding protein
NCBI Synonym Full Names:calcyclin binding protein
NCBI Official Symbol:CACYBP  
NCBI Official Synonym Symbols:SIP; GIG5; PNAS-107; S100A6BP  
NCBI Protein Information:calcyclin-binding protein; hCacyBP; S100A6-binding protein; Siah-interacting protein (SIP); growth-inhibiting gene 5 protein
UniProt Protein Name:Calcyclin-binding protein
UniProt Synonym Protein Names:S100A6-binding protein; Siah-interacting protein
Protein Family:Calcyclin-binding protein
UniProt Gene Name:CACYBP  
UniProt Entry Name:CYBP_HUMAN
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