Human CAB39L Recombinant Protein (RPPB2957)
- SKU:
- RPPB2957
- Product type:
- Recombinant Protein
- Size:
- 20ug
- Species:
- Human
- Target:
- CAB39L
- Synonyms:
- MO25-BETA
- MO2L
- MLAA-34
- Mo25-like protein
- Source:
- Escherichia Coli
- Uniprot:
- Q9H9S4
Description
| Product Name: | Human CAB39L Recombinant Protein |
| Product Code: | RPPB2957 |
| Size: | 20µg |
| Species: | Human |
| Target: | CAB39L |
| Synonyms: | MO25-BETA, MO2L, MLAA-34, Mo25-like protein. |
| Source: | Escherichia Coli |
| Physical Appearance: | Sterile filtered colorless solution. |
| Formulation: | CAB39L protein solution (0.5mg/ml) contains 20mM Tris-HCl buffer (pH 8.0), 0.1M NaCl,10% glycerol and 1mM DTT. |
| Stability: | Store at 4°C if entire vial will be used within 2-4 weeks. Store, frozen at -20°C for longer periods of time. For long term storage it is recommended to add a carrier protein (0.1% HSA or BSA).Avoid multiple freeze-thaw cycles. |
| Purity: | Greater than 95.0% as determined by SDS-PAGE. |
| Amino Acid Sequence: | MGSSHHHHHH SSGLVPRGSH MGSMKKMPLF SKSHKNPAEI VKILKDNLAI LEKQDKKTDK ASEEVSKSLQ AMKEILCGTN EKEPPTEAVA QLAQELYSSG LLVTLIADLQ LIDFEGKKDV TQIFNNILRR QIGTRSPTVE YISAHPHILF MLLKGYEAPQ IALRCGIMLR ECIRHEPLAK IILFSNQFRD FFKYVELSTF DIASDAFATF KDLLTRHKVL VADFLEQNYD TIFEDYEKLL QSENYVTKRQ SLKLLGELIL DRHNFAIMTK YISKPENLKL MMNLLRDKSP NIQFEAFHVF KVFVASPHKT QPIVEILLKN QPKLIEFLSS FQKERTDDEQ FADEKNYLIK QIRDLKKTAP |
Calcium-binding protein 39-like (CAB39L), is analogous to MO25 and located in the serum of virtually half of all patients diagnosed with acute monocytic leukemia. CAB39L plays a role in carcinogenesis. Furthermore, LKB1 activity raises upon the binding of a regulatory complex consisting of the STE20-related adaptor-alpha (STRAD alpha) pseudo kinase and the CAB39L.
CAB39L Human Recombinant produced in E.Coli is a single, non-glycosylated polypeptide chain containing 360 amino acids (1-337a.a) and having a molecular mass of 41.5kDa. CAB39L is fused to a 23 amino acid His-tag at N-terminus & purified by proprietary chromatographic techniques.
| UniProt Protein Function: | CAB39L: Component of a complex that binds and activates STK11/LKB1. In the complex, required to stabilize the interaction between CAB39/MO25 (CAB39/MO25alpha or CAB39L/MO25beta) and STK11/LKB1. Belongs to the Mo25 family. |
| UniProt Protein Details: | Chromosomal Location of Human Ortholog: 13q14.2 Cellular Component: cytosol Biological Process: insulin receptor signaling pathway; cell cycle arrest |
| UniProt Code: | Q9H9S4 |
| NCBI GenInfo Identifier: | 51338824 |
| NCBI Gene ID: | 81617 |
| NCBI Accession: | Q9H9S4.3 |
| UniProt Related Accession: | Q9H9S4 |
| Molecular Weight: | |
| NCBI Full Name: | Calcium-binding protein 39-like |
| NCBI Synonym Full Names: | calcium binding protein 39 like |
| NCBI Official Symbol: | CAB39L |
| NCBI Official Synonym Symbols: | MO2L; MO25-BETA; bA103J18.3 |
| NCBI Protein Information: | calcium-binding protein 39-like |
| UniProt Protein Name: | Calcium-binding protein 39-like |
| UniProt Synonym Protein Names: | Antigen MLAA-34; MO25beta; Mo25-like protein |
| UniProt Gene Name: | CAB39L |
| UniProt Entry Name: | CB39L_HUMAN |
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