Human C1QTNF1 Recombinant Protein (RPPB2939)

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SKU:
RPPB2939
Product type:
Recombinant Protein
Size:
10ug
Species:
Human
Target:
C1QTNF1
Synonyms:
GIP
Synonyms:
CTRP1
Synonyms:
ZSIG37
Synonyms:
FLJ90694
Source:
Escherichia Coli
Uniprot:
Q9BXJ1
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Description

Product Name:Human C1QTNF1 Recombinant Protein
Product Code:RPPB2939
Size:10µg
Species:Human
Target:C1QTNF1
Synonyms:GIP, CTRP1, ZSIG37, FLJ90694, C1QTNF1, Complement C1q Tumor Necrosis Factor-Related Protein 1, G protein-coupled receptor-interacting protein.
Source:Escherichia Coli
Formulation:Human C1QTNF1 was lyophilized from 50mM Acetate Buffer pH-4.
Solubility:Add 0.1M Acetate buffer pH4 to prepare a working stock solution of approximately 0.5mg/mL and let the lyophilized pellet dissolve completely. For conversion into higher pH value, we recommend intensive dilution by relevant buffer to a concentration of 10?g/ml. In higher concentrations the solubility of this antigen is limited. Product is not sterile! Please filter the product by an appropriate sterile filter before using it in the cell culture.
Stability:Store lyophilized protein at -20°C. Aliquot the product after reconstitution to avoid repeated freezing/thawing cycles. Reconstituted protein can be stored at 4°C for a limited period of time; it does not show any change after two weeks at 4°C.
Purity:Greater than 95% as determined by SDS PAGE.
Amino Acid Sequence:MKHHHHHHAS RVPHVQGEQQ EWEGTEELPS PPDHAERAEE QHEKYRPSQD QGLPASRCLR CCDPGTSMYP ATAVPQINIT ILKGEKGDRG DRGLQGKYGK TGSAGARGHT GPKGQKGSMG APGERCKSHY AAFSVGRKKP MHSNHYYQTV IFDTEFVNLY DHFNMFTGKF YCYVPGLYFF SLNVHTWNQK ETYLHIMKNE EEVVILFAQV GDRSIMQSQS LMLELREQDQ VWVRLYKGER ENAIFSEELD TYITFSGYLVKHATEP

C1QTNF1 is a novel adipokine, providing a significant framework to further address the physiological functions and mechanisms of the action of this family of secreted glycoproteins in normal and disease states. C1QTNF1 increases the production of aldosterone. C1QTNF1 is vastly expressed in obese subjects as well as up-regulated in hypertensive patients, C1QTNF1 is identified molecular link between obesity and hypertension. C1QTNF1 expression may be associated with a low-grade chronic inflammation status in adipose tissues.

C1QTNF1 Human Recombinant produced in E.Coli is a single, non-glycosylated, Polypeptide chain containing 266 amino acids and having a molecular mass of 30.45 kDa. The protein contains an extra His tag at N-terminus. The C1QTNF1 amino acid sequence is identical to UniProtKB/Swiss-Prot entry Q9BXJ1 amino acids 26–281.The C1QTNF1 is purified by proprietary chromatographic techniques.

UniProt Protein Function:C1QTNF1: 2 isoforms of the human protein are produced by alternative splicing
UniProt Protein Details:

Protein type:Secreted, signal peptide; Secreted

Chromosomal Location of Human Ortholog: 17q25.3

Cellular Component: extracellular space; integral to plasma membrane

Molecular Function:collagen binding; protein binding

Biological Process: elevation of cytosolic calcium ion concentration

UniProt Code:Q9BXJ1
NCBI GenInfo Identifier:20177862
NCBI Gene ID:114897
NCBI Accession:Q9BXJ1.1
UniProt Secondary Accession:Q9BXJ1,Q6ZMH6, Q96NF2, Q9GZR4,
UniProt Related Accession:Q9BXJ1
Molecular Weight:32,760 Da
NCBI Full Name:Complement C1q tumor necrosis factor-related protein 1
NCBI Synonym Full Names:C1q and tumor necrosis factor related protein 1
NCBI Official Symbol:C1QTNF1  
NCBI Official Synonym Symbols:GIP; CTRP1; ZSIG37  
NCBI Protein Information:complement C1q tumor necrosis factor-related protein 1
UniProt Protein Name:Complement C1q tumor necrosis factor-related protein 1
UniProt Synonym Protein Names:G protein-coupled receptor-interacting protein; GIP
Protein Family:Complement C1q tumor necrosis factor-related protein
UniProt Gene Name:C1QTNF1  
UniProt Entry Name:C1QT1_HUMAN
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