Human C12ORF5 Recombinant Protein (RPPB2927)

(No reviews yet) Write a Review

제품 코드를 사용하여 Assay Genie 메인 사이트를 통해 주문합니다.

주문
SKU:
RPPB2927
Product type:
Recombinant Protein
Size:
10ug
Species:
Human
Target:
C12ORF5
Synonyms:
Probable fructose-2
Synonyms:
6-bisphosphatase TIGAR
Synonyms:
TP53-induced glycolysis and apoptosis regulator
Synonyms:
TIGAR
Source:
Escherichia Coli
Uniprot:
Q9NQ88
€0.00
Frequently bought together:

Description

Product Name:Human C12ORF5 Recombinant Protein
Product Code:RPPB2927
Size:10µg
Species:Human
Target:C12ORF5
Synonyms:Probable fructose-2,6-bisphosphatase TIGAR, TP53-induced glycolysis and apoptosis regulator, TIGAR, C12orf5.
Source:Escherichia Coli
Physical Appearance:Sterile Filtered colorless solution.
Formulation:The C12ORF5 solution (0.5 mg/ml) contains 20mM Tris-HCl buffer (pH8.0), 0.2M NaCl, 2mM DTT and 10% glycerol.
Stability:Store at 4°C if entire vial will be used within 2-4 weeks. Store, frozen at -20°C for longer periods of time. For long term storage it is recommended to add a carrier protein (0.1% HSA or BSA).Avoid multiple freeze-thaw cycles.
Purity:Greater than 90.0% as determined by SDS-PAGE.
Amino Acid Sequence:MGSSHHHHHH SSGLVPRGSH MGSHMARFAL TVVRHGETRF NKEKIIQGQG VDEPLSETGF KQAAAAGIFL NNVKFTHAFS SDLMRTKQTM HGILERSKFC KDMTVKYDSR LRERKYGVVE GKALSELRAM AKAAREECPV FTPPGGETLD QVKMRGIDFF EFLCQLILKE ADQKEQFSQG SPSNCLETSL AEIFPLGKNH SSKVNSDSGI PGLAASVLVV SHGAYMRSLF DYFLTDLKCS LPATLSRSEL MSVTPNTGMS LFIINFEEGR EVKPTVQCIC MNLQDHLNGL TETR

TP53-induced glycolysis and apoptosis regulator (TIGAR or C12ORF5), is a 270 amino acid protein induced by the p53 tumor suppressor pathway that functions to protect against oxidative stress. C12ORF5 specifically functions to block glycolysis, leading the pathway to the pentose phosphate shunt and decreasing the intracellular concentration of reactive oxygen species. Therefore, it is thought that C12ORF5 may act to modulate the apoptotic response to p53, thus allowing cells to survive mild or transient stresses.

C12ORF5 Human Recombinant fused with a 24 amino acid His tag at N-terminus produced in E.Coli is a single, non-glycosylated, polypeptide chain containing 294 amino acids (1-270 a.a.) and having a molecular mass of 32.6kDa. The C12ORF5 is purified by proprietary chromatographic techniques.

UniProt Protein Function:TIGAR: Fructose-bisphosphatase hydrolyzing fructose-2,6- bisphosphate as well as fructose-1,6-bisphosphate. Inhibits glycolysis by reducing cellular levels of fructose-2,6- bisphosphate. May protect cells against reactive oxygen species and against apoptosis induced by tp53. Belongs to the phosphoglycerate mutase family.Protein type: EC 3.1.3.46; Phosphatase (non-protein)Chromosomal Location of Human Ortholog: 12p13.3Cellular Component: cytoplasm; cytosol; intracellular; mitochondrial outer membrane; nucleusMolecular Function: bisphosphoglycerate phosphatase activity; fructose-2,6-bisphosphate 2-phosphatase activity; protein bindingBiological Process: apoptosis; autophagy; dephosphorylation; fructose 1,6-bisphosphate metabolic process; fructose 2,6-bisphosphate metabolic process; gene expression; negative regulation of glycolysis; negative regulation of programmed cell death; positive regulation of DNA repair; regulation of pentose-phosphate shunt; response to DNA damage stimulus; response to gamma radiation; response to xenobiotic stimulus; transcription initiation from RNA polymerase II promoter
UniProt Protein Details:
NCBI Summary:This gene is regulated as part of the p53 tumor suppressor pathway and encodes a protein with sequence similarity to the bisphosphate domain of the glycolytic enzyme that degrades fructose-2,6-bisphosphate. The protein functions by blocking glycolysis and directing the pathway into the pentose phosphate shunt. Expression of this protein also protects cells from DNA damaging reactive oxygen species and provides some protection from DNA damage-induced apoptosis. The 12p13.32 region that includes this gene is paralogous to the 11q13.3 region. [provided by RefSeq, Jul 2008]
UniProt Code:Q9NQ88
NCBI GenInfo Identifier:74734311
NCBI Gene ID:57103
NCBI Accession:Q9NQ88.1
UniProt Secondary Accession:Q9NQ88,B2R840
UniProt Related Accession:Q9NQ88
Molecular Weight:30,063 Da
NCBI Full Name:Fructose-2,6-bisphosphatase TIGAR
NCBI Synonym Full Names:TP53 induced glycolysis regulatory phosphatase
NCBI Official Symbol:TIGAR  
NCBI Official Synonym Symbols:FR2BP; C12orf5  
NCBI Protein Information:fructose-2,6-bisphosphatase TIGAR
UniProt Protein Name:Fructose-2,6-bisphosphatase TIGAR
UniProt Synonym Protein Names:TP53-induced glycolysis and apoptosis regulator
Protein Family:Fructose-2,6-bisphosphatase
UniProt Gene Name:TIGAR  
UniProt Entry Name:TIGAR_HUMAN
View AllClose

Related Products