Human BTLA Recombinant Protein (RPPB2915)

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SKU:
RPPB2915
Product type:
Recombinant Protein
Size:
10ug
Species:
Human
Target:
BTLA
Synonyms:
B- and T-lymphocyte attenuator
Synonyms:
B- and T-lymphocyte-associated protein
Synonyms:
CD272
Synonyms:
B And T Lymphocyte Associated
Source:
Sf9 Insect cells
Uniprot:
Q7Z6A9
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Description

Product Name:Human BTLA Recombinant Protein
Product Code:RPPB2915
Size:10µg
Species:Human
Target:BTLA
Synonyms:B- and T-lymphocyte attenuator, B- and T-lymphocyte-associated protein, CD272, B And T Lymphocyte Associated, B- And T-Lymphocyte-Associated Protein, B- And T, Lymphocyte Attenuator, CD272 Antigen, BTLA1.
Source:Sf9 Insect cells
Physical Appearance:Sterile filtered colorless solution.
Formulation:BTLA protein solution (0.5mg/ml) contains Phosphate Buffered Saline (pH 7.4) and 10% glycerol.
Stability:Store at 4°C if entire vial will be used within 2-4 weeks. Store, frozen at -20°C for longer periods of time. For long term storage it is recommended to add a carrier protein (0.1% HSA or BSA).Avoid multiple freeze-thaw cycles.
Purity:Greater than 90.0% as determined by SDS-PAGE.
Amino Acid Sequence:ADPKESCDVQ LYIKRQSEHS ILAGDPFELE CPVKYCANRP HVTWCKLNGT TCVKLEDRQT SWKEEKNISF FILHFEPVLP NDNGSYRCSA NFQSNLIESH STTLYVTDVK SASERPSKDE MASRPWLLYS HHHHHH

BTLA, also known as B And T Lymphocyte Associated, is an inhibitory molecule which is part of the Ig superfamily. BTLA is a type 1 transmembrane glycoprotein in the CD28 family of T cell costimulatory molecules. BTLA is a 3rd inhibitory receptor on T lymphocytes with resemblances to CTLA-4 & PD-1. Moreover, BTLA is a ligand for TNF (receptor) superfamily, TNFRSF14, and HVEM. BTLA-HVEM complexes negatively regulate T-cell immune responses.

BTLA produced in Sf9 Insect cells is a single, glycosylated polypeptide chain containing 136 amino acids (31-157 a.a.) and having a molecular mass of 15.7kDa (Molecular size on SDS-PAGE will appear at approximately 18-28kDa).BTLA is expressed with a 9 amino acid His tag at C-Terminus and purified by proprietary chromatographic techniques.

UniProt Protein Function:Lymphocyte inhibitory receptor which inhibits lymphocytes during immune response.
NCBI Summary:This gene encodes a member of the immunoglobulin superfamily. The encoded protein contains a single immunoglobulin (Ig) domain and is a receptor that relays inhibitory signals to suppress the immune response. Alternative splicing results in multiple transcript variants. Polymorphisms in this gene have been associated with an increased risk of rheumatoid arthritis. [provided by RefSeq, Aug 2011]
UniProt Code:Q7Z6A9
NCBI GenInfo Identifier:296439425
NCBI Gene ID:151888
NCBI Accession:Q7Z6A9.3
UniProt Secondary Accession:Q7Z6A9,Q3B831, Q3HS85, Q6ZNH9,
UniProt Related Accession:Q7Z6A9
Molecular Weight:27,317 Da
NCBI Full Name:B- and T-lymphocyte attenuator
NCBI Synonym Full Names:B and T lymphocyte associated
NCBI Official Symbol:BTLA  
NCBI Official Synonym Symbols:BTLA1; CD272  
NCBI Protein Information:B- and T-lymphocyte attenuator
UniProt Protein Name:B- and T-lymphocyte attenuator
UniProt Synonym Protein Names:B- and T-lymphocyte-associated protein; CD_antigen: CD272
Protein Family:B- and T-lymphocyte attenuator
UniProt Gene Name:BTLA  
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